Аннотация
Введение. Окислительный стресс (ОС) возникает при различных патологических процессах, выступая в качестве неспецифического звена их патогенеза. Меньше известно о его физиологической роли. Цель. Анализ результатов данных мировой литературы и собственных исследований об участии ОС в формировании процессов адаптации в организме, в условиях воздействия на него неблагоприятных факторов внешней среды. Методы. Анализ результатов исследований, опубликованных в российских и международных базах данных (Pubmed, Elsevier), касающихся физиологической роли ОС, опубликованных за последние 20 лет. Результаты. В статье представлены многочисленные сведения о том, что ОС выступает в роли неспецифического звена адаптации организма. Реализация его физиологических эффектов связана с изменением редокс-состояния цитоплазмы и митохондрий клетки, что приводит к обратимому окислению внутриклеточных белков и способствует модуляции их свойств. В результате этого изменяется синтез и модулируется проявление активности целого ряда внутриклеточных белков (ферментов, шаперонов, факторов транскрипции), обеспечивающих защиту от действия повреждающих факторов. Заключение. Авторы делают заключение о нецелесообразности использования антиоксидантов для лечения и профилактики заболеваний, патогенез которых связан с возникновением умеренного ОС (окислительного эустресса).
Авторы и аффилиации
В.В. Давыдов(1, 2), А.В. Шестопалов(1–3, С.А. Румянцев1, 2
1Российский национальный исследовательский медицинский
университет им. Н.И. Пирогова Минздрава России,
Российская Федерация, 117997, Москва, ул. Островитянова, д. 1;
2Национальный медицинский исследовательский центр эндокринологии Минздрава России,
Российская Федерация, 115478, Москва, ул. Дмитрия Ульянова, д. 11;
3Национальный медицинский исследовательский центр
детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева,
Российская Федерация, 117997, Москва, ул. Саморы Машела, д. 1
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