Аннотация
Цель исследования. Анализ современных достижений в области применения нанотехнологий для создания таргетных препаратов в онкологии, включая механизмы их действия и перспективы клинического применения. Материал и методы. Проведен комплексный анализ научной литературы по применению нанотехнологий в разработке противоопухолевых препаратов. Использованы базы данных PubMed, Scopus и Web of Science за период 2000–2024 гг. Результаты. Систематизированы основные типы наночастиц, применяемых в онкологии, их физико-химические свойства и механизмы доставки в опухолевую ткань. Описаны принципы EPR-эффекта и стратегии улучшения целевой доставки препаратов. Проанализированы современные подходы к модификации наночастиц для повышения их терапевтической эффективности. Заключение. Нанотехнологии представляют собой перспективное направление в разработке противоопухолевых препаратов, позволяющее повысить эффективность и безопасность терапии. Применение наносистем доставки лекарств способствует преодолению биологических барьеров и улучшению фармакокинетических параметров препаратов.
Ключевые слова
Авторы и аффилиации
П.В. Селивёрстов(1), А.Д. Бакшеева(2), П.С. Корецкая(3), И.З. Абдусаттаров(4)
1-ФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова» МО РФ,
Российская Федерация, 194044, Санкт-Петербург, ул. Лебедева, д. 6;
2-Федеральное государственное автономное образовательное учреждение высшего образования
«Российский университет дружбы народов имени Патриса Лумумбы»,
Российская Федерация, 117198, Москва, ул. Миклухо-Маклая, д. 6;
3-ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский Университет),
Российская Федерация, 117513, Москва, ул. Островитянова, д. 1;
4-Федеральное государственное бюджетное образовательное учреждение
высшего образования «Оренбургский государственный медицинский университет»
Министерства здравоохранения Российской Федерации,
Российская Федерация, 460014, Оренбургская обл., Оренбург, ул. Советская, здание №6
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