Аннотация
Диагностика ранних стадий Т-клеточных лимфом кожи (ТКЛК) – одна из наиболее сложных задач дерматологии сегодня. Данный обзор посвящен анализу новых иммуногистохимических (ИГХ) маркеров, которые можно рассматривать в качестве диагностических для распознавания ТКЛК, а также потенциальным мишенями для таргетной терапии заболевания. Целью исследования было суммировать новые перспективные биомаркеры, не используемые в настоящее время для диагностики ранних стадий ТКЛК. Материал и методы. Анализ и систематизация научной литературы за последние 5 лет выполнен в базе данных PubMed по алгоритму поиска: «кожная Т-клеточная лимфома» И («иммуногистохимия» ИЛИ «ИГХ» ИЛИ «экспрессия»). Результаты. Все найденные биомаркеры были разделены на 3 группы: • маркеры прогрессии опухоли OX40, OX40L, ICOS, TOX, GATA-3, TSP-1, CD47, YKL-40, IKZF2, E-FABP, CXCR4, CD69, HSPA1A, ZFP36, TXNIP и IL7R; • дифференциально-диагностические маркеры STAT4, YKL-40, BCL11B, CD70, hBD-2 и psoriasin; • маркеры микроокружения опухоли IL10, PD-L1, FAP-α, CD69, granzyme B, NKp46, TIM3, CD57 и LAG3. Заключение. Наиболее перспективным маркером для диагностики ранних стадий является YKL-40, так как он может служить одновременно прогностическим и дифференциально-диагностическим.
Ключевые слова
Авторы и аффилиации
О.А. Гафурова, О.Н. Данилик, О.В. Ануфриева,
Я.В. Сыроватская, М.А. Оробец, Р.А. Артыкова,
Е.А. Гостеева, Е.Е. Руденко, В.А. Смольянникова
ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет),
Российская Федерация, 119048, Москва, ул. Трубецкая, д. 8, стр. 2
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