Аннотация
Настоящий обзор был проведен с целью систематизации данных о взаимосвязи полиморфизмов генов матриксных протеиназ (MMP, ADAMTS, ADAM) с риском развития остеоартрита (ОА). Материал и методы. Систематический поиск литературы в базах данных PubMed и Web of Science за период 2003–2024 гг. Результаты. Выявлена значительная этническая и популяционная гетерогенность в распределении генетических ассоциаций. Наиболее убедительные данные получены для полиморфизмов генов ADAMTS-5 (rs2830585, rs2249350) и ADAMTS-14 (rs4747096), демонстрирующих воспроизводимые ассоциации в различных популяциях. При этом для многих других генов-кандидатов (ADAMTS-7, -12, MMP-1, -3, -13) наблюдаются противоречивые результаты, обусловленные как методологическими особенностями исследований, так и истинными популяционными различиями. Заключение. Полученные данные подчеркивают сложный полигенный характер наследственной предрасположенности к ОА и необходимость интеграции генетических данных с функциональными исследованиями для установления причинно-следственных связей.
Ключевые слова
Авторы и аффилиации
А.Н. Воронова, Н.Г. Плехова
Федеральное государственное бюджетное образовательное учреждение высшего образования
«Тихоокеанский государственный медицинский университет» Министерства здравоохранения
Российской Федерации, Российская Федерация, 690002, Владивосток, пр-т Острякова, д. 2
Литература
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