Аннотация
Метаболический синдром (МС) представляет собой кластер состояний, таких как абдоминальное ожирение, гипертония, дислипидемия и гипергликемия, которые очень распространены в развитых странах. Распространенность МС увеличивается ежегодно. В последние годы наблюдается заметный рост распространенности МС среди молодежи. На сегодняшний день изучаются различные маркеры, представляющие ценность для понимания данной патологии. Цель. Обобщить современные представления о диагностической значимости биомаркеров (в том числе витамина D, магния, омега-3 индекса) и расчетных коэффициентов (HOMA-IR, TyG, FLI и др.) в патогенезе и клиническом ведении метаболического синдрома (МС), а также их связи с гастроэнтерологической патологией – неалкогольной жировой болезнью печени, кишечной микробиотой и хроническим воспалением. Материал и методы. Проведен обзор литературы (PubMed, Scopus, eLIBRARY) за 2018–2024 гг., включающий оригинальные исследования, метаанализы и клинические рекомендации. Проанализированы уровни витамина D, магния, омега-3 индекса и их связь с компонентами МС и сопутствующими нарушениями желудочно-кишечного тракта.
Ключевые слова
Авторы и аффилиации
В.И. Быстрова(1, 2), Е.В. Шрайнер(1, 2),
Г.И. Лифшиц(1, 2), Д.А. Кудлай(3–5)
1-ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет»,
Российская Федерация, 630090, Новосибирск, ул. Пирогова, 1; 2-Институт химической биологии
и фундаментальной медицины СО РАН, Российская Федерация, Новосибирск, 630090,
ул. Академика Лаврентьева, 8; 3-ФГАОУ ВО Первый Московский государственный медицинский
университет им. И.М. Сеченова Минздрава России (Сеченовский Университет),
Российская Федерация, 119991, Москва, ул. Трубецкая, д. 8, стр. 2; 4-ФГБОУ ВПО
«Московский государственный университет им. М.В. Ломоносова», Российская Федерация,
119991, Москва, Ленинские горы, 1; 5-ФГБУ «ГНЦ Институт иммунологии» ФМБА России,
Российская Федерация, 115522, Москва, Каширское шоссе, д. 24
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