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Данный обзор является попыткой обобщения современных данных о роли микроРНК в патогенезе эндометриоза и их патогенетической связи с основными патоморфологическими проявлениями при данной патологии. На сегодняшний день исследуется большое количество микроРНК с …
Ulcerative colitis and Crohn’s disease represent one of the most pressing problems of modern medicine. Even though much attention paid to the development and implementation of high-tech diagnostic methods, inflammatory bowel diseases (IBD) tend to increase in …
Cutaneous melanoma is a highly heterogeneous malignancy, which characterized by low effectiveness of chemotherapeutic antitumor agents. 50% of melanomas have a somatic mutation in BRAF oncogene, leading to uncontrolled activation of mitogen-activated protein k…
Iron is an essential trace element not only for the human body, but also for some microorganisms, including mycobacterium tuberculosis. Being strict aerobes, mycobacteria receive iron from the human body using the siderophore transporter system. Iron deficienc…
Communities of microorganisms are a set of species that interact with each other and occupy the same niche where competitive or mutually beneficial relationships can occur. Biofilms are only one of many types of microbial communities, the study of which has be…
The review considers the role of hyaluronic acid (HA), primarily low-molecular-weight fractions of HA, in the regulation of the cell cycle of tumor cells. The formation of a pool of low-molecular weight HA molecules is due to the high activity of hyaluronidase…
Progress in clinical research and medicine has contributed to a significant reduction in the worldwide mortality rate. Currently, the strategy of developed countries is directed at increasing expectancy and improving life quality. As a consequence, the modern …
The problems of longevity increase and its quality improvement are actual for the modern gerontology. So far it is necessary to complete tasks of early diagnostic and target prophylactic of the age-associated pathology. There are presented the data concerning …
The review considers the system of hyaluronic acid (HA), represented by its receptors, the enzymes of synthesis (hyaluronan synthase), cleavage (hyaluronidase). The participation of the HA system in the regulation of the cell cycle was demonstrated. The most i…
Меланома кожи является крайне гетерогенным злокачественным новообразованием, что обеспечивало традиционно низкую эффективность химиотерапевтических противоопухолевых препаратов. В 2002 г. было выявлено, что порядка 50% меланом имеют соматическую мутацию в онко…