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Molecular Medicine
Introduction. Recurrent miscarriage (RM) – a prevalent pathology in women. However, the mechanisms of its occurrence are studied insufficiently. A genetic factor may be one of the causes of RM in women. The aim of the study was to investigate the association o…
Introduction authors made an attempt to demonstrate the role of DNA-methylation in pathogenesis of uterine fibroids. The epigenetic aspects based on personal investigations and literary data have been reviewed. The research underlined a perspective of investig…
Objective to analyze own data on diagnostics, morphological verification and treatment of the splenic hamartoma, and compare them with the previous research results. Materials and Methods. More than 300 patients with various focal lesions of the spleen have be…
Introduction. Insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignant tumors including colorectal cancer (CRC), so far its components are considered as potential diagnostic and prognostic markers…
ntroduction. Agr2protein belongs to the family of disulfide isomerases of the endoplasmic reticulum and contains active cysteine domains involved in the formation of disulfide bonds with mucins. It is expressed in goblet cells of the intestinal epithelium and …
Introduction. Fibroadenomatosis (FAM) is a heterogeneous group of pathological conditions of the mo-Nochnoi gland, with hormone-dependent nature and different degree of risk maligni of the organization. The use of routine histological stains is not enough to d…
Introduction. The gain of elderly persons in the population of industrial countries provides a high actuality to investigations of pathogenesis of calcific aortic valve stenosis (CAVS). The aim of the study. To specify the quality and quantity pattern of colla…
Introduction. Erysipelas is characterized by consistently high morbidity rate, pronounced tendency to recur, the frequent change of lymph circulation, formation of secondary elephantiasis and others symptoms. The prediction of the course of erysipelas is unres…
Introduction. Taken into account the literature data on the leading role of perceptual deficit in the pathogenesis of schizophrenia and the lack of experimental models of this impairment we proposed the novel test of instinctive aversion (TIA). The work was pe…
Introduction. Skin melanoma is referred to hormone-dependent tumors, the mechanism of influence of endocrine factors on pathogenesis of the tumor, however, has not been determined so far The aim of the study. The studying of the level of steroid hormones, prol…
Introduction. One of the most prospective approaches in therapy of deep skin burns is the development of artificial dermal equivalents with a potential to provide efficient scaffolding for dermis reconstruction and re-epithelisation. The choice of material for…
Introduction. Epigenetic changes caused by methylation in promoter CpG-islands are a fine and dynamic mechanism of gene expression regulation in tumors. Increased and decreased expression and alterations in the methylation status of the gene are considered to …