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Molecular Medicine
Introduction. The antitumor effects of selenium compounds depend on their structure and biotransformation. Toxic metabolite formation may coexist with enhanced selenoprotein-mediated protection of tumor cells; chemical reactivity does not establish therapeutic…
Material and methods. A literature search was conducted in the PubMed/MEDLINE, Web of Science, Scopus, eLibrary.Ru, and Google Scholar for the period from 2022 to 2026. The search string included the following keywords: “leiomyoma”, “uterine leiomyoma”, “fibro…
Aim. To relate data on the molecular mechanisms of primary dysmenorrhea to the main dimensions of its clinical heterogeneity: pain severity and duration, systemic symptoms, response to nonsteroidal anti-inflammatory drugs (NSAIDs), and propensity to chronic pa…
Introduction. Macrophage polarization is a key mechanism of immune regulation that determines their functional plasticity. Depending on the microenvironment, macrophages differentiate into proinflammatory (M1, activated by IFN-γ and LPS) or anti-inflammatory (…
Objective. To relate hormonal, osteoimmune, and metabolic regulation of bone remodeling during the menopause transition to clinical evidence. Material and methods. A narrative analysis covered publications identified through PubMed and journal and professional…
Introduction. The efficacy of RNA interferon inducers depends not only on ligand structure and innate immune receptor engagement but also on the metabolic state of the target cell. Increasing evidence indicates that redox homeostasis, glutathione system parame…
Relevance. Tuberculosis immunodiagnostics is based on the ESAT-6 and CFP-10 antigens (RD1 region of Mycobacterium tuberculosis), which are absent from BCG strains and form the antigenic basis of IGRA and TBST. Their clinical use requires consideration of sever…
Introduction. Sorcin is a protein that regulates calcium concentration in the endoplasmic reticulum in normal and cancer cells. The role of sorcin in the pathogenesis of oncological diseases is well known. However, its role in ontogenesis and development of br…
Objective. To summarize data on the role of interleukin-2 (IL-2) in the immunopathogenesis of rheumatoid arthritis (RA), evaluate the clinical experience with low-dose IL-2 (ldIL-2) therapy in RA, and determine the prospects for Treg-selective IL-2-based agent…
Objective. To summarize data on the role of interleukin-2 (IL-2) in the immunopathogenesis of rheumatoid arthritis (RA), evaluate the clinical experience with low-dose IL-2 (ldIL-2) therapy in RA, and determine the prospects for Treg-selective IL-2-based agent…
Background. Bronchobstructive diseases are accompanied by changes in autonomic and hemodynamic regulation. Nonlinear characteristics of circulatory rhythms may serve as integrative functional features of individual rehabilitation response, but they are not dir…
Objective. The extracellular matrix (ECM) plays a key role in glioblastoma (GB) progression by shaping an immunosuppressive tumor microenvironment and acting as a drug penetration barrier. This study performed an integrative analysis of seven publicly availabl…