Abstract
Introduction. Sorcin is a protein that regulates calcium concentration in the endoplasmic reticulum in normal and cancer cells. The role of sorcin in the pathogenesis of oncological diseases is well known. However, its role in ontogenesis and development of bronchopulmonary system diseases hasn’t been studied sufficiently.
The aim of the review is to analyze the molecular aspects of involvement of sorcin in the regulation of lung functions during ontogenesis, in bronchial asthma, and in chronic obstructive pulmonary disease (COPD).
Methodology for searching and analyzing information. The systematic review of studies on the selected topic was conducted in accordance with the methodology recommended in the PRISMA 2020 protocol (The Preferred Reporting Items for Systematic reviews and Meta Analyses). Publications were searched in PubMed, Scopus, Web of Science, and RSCI databases for the period from 2006 to 2025.
Results. Analysis of literature from the aforementioned databases demonstrated that sorcin normalizes the synthesis of surfactant proteins SP-B and SP-C and growth factor FGF10 in lung tissue during bronchial asthma. This facilitates the suppression of the inflammatory response through the deactivation of the PI3K/AKT/NF-κB signaling pathway. Furthermore, sorcin activates the synthesis of the lipid transport protein ABCA3 and inhibits the excessive activity of the RAS protein-key components in the pathogenesis of COPD.
Conclusion. Thus, sorcin can be considered as a potential molecular target for improving the effectiveness of treatment of bronchial asthma and COPD.
Authors and affiliations
https://elibrary.ru/kzjgpc N.S. Linkova(1), E.S. Mironova(1), T.S. Zubareva(1), T.V. Kvetnaya(2), Yu.S. Krylova(1),
1-Saint-Petersburg State Budgetary Institution “Saint-Petersburg Scientific Research Institute of Phthisiopulmonology”
of the Ministry of Health of the Russian Federation, Ligovsky Ave., 2/4, Saint-Petersburg, 191036, Russian Federation;
2-Higher Scientific Research Center “Saint-Petersburg Institute of Bioregulation and Gerontology”,
Dynamo pr. 3, Saint-Petersburg, 197110, Russian Federation
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