Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Metabolism of fucoglycoproteins in the gastrointestinal tract of immobilized rats with fatty liver disease under the administration of SAMe
Introduction. The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is based on lipid accumulation in hepatocytes accompanied by oxidative stress and the development of steatohepatitis, whereas the etiology of alcoholic liver disease (ALD) is associate…
Factors associated with DOAC-related complications in older patients with multimorbidity and polypharmacy
Objective. To assess the association of age, anaemia, impaired renal function and concomitant therapy with direct oral anticoagulant (DOAC)-related outcomes in patients aged 60 years and older with multimorbidity and polypharmacy. Material and methods. This pr…
Comparison of tyrosine hydroxylase and 3‑nitrotyrosine expression in a rotenone model of Parkinson’s disease and an early‑life stress model
Introduction. Despite research into the pathogenesis of depression in PD, there is still no unified theory regarding its onset. Objective: To evaluate the expression of tyrosine hydroxylase (TH) and 3-nitrotyrosine (3-NT) in brain structures using models of PD…
EPIGENETIC CHANGES IN COLORECTAL CANCER: THE ROLE OF SEPT9 METHYLATION IN THE DIAGNOSIS AND PROGNOSIS OF THE DISEASE COURSE
Introduction. Colorectal cancer (CRC) remains one of the leading oncological diseases, the development of which is accompanied by characteristic epigenetic changes. The most significant of these is the hypermethylation of the SEPT9 gene, detected both in tumor…
Rationale for the use of N-acetylcysteine as a radioprotector during liver irradiation
Introduction. Radiotherapy carries a risk of liver damage: radiation-induced liver disease develops in 5 – 10% of cases after gamma-irradiation at 30 Gy, driven by oxidative stress and depletion of endogenous antioxidant defense. Existing radioprotectors, such…
Core matrisome gene signatures in glioblastoma
Objective. The extracellular matrix (ECM) plays a key role in glioblastoma (GB) progression by shaping an immunosuppressive tumor microenvironment and acting as a drug penetration barrier. This study performed an integrative analysis of seven publicly availabl…
Functional hemodynamic response profiles following pulmonary rehabilitation: a pilot study in the context of personalized medicine
Background. Bronchobstructive diseases are accompanied by changes in autonomic and hemodynamic regulation. Nonlinear characteristics of circulatory rhythms may serve as integrative functional features of individual rehabilitation response, but they are not dir…
ОБЗОРЫ
Pathogenesis of minimal hepatic encephalopathy
Objective. To summarize data on the role of interleukin-2 (IL-2) in the immunopathogenesis of rheumatoid arthritis (RA), evaluate the clinical experience with low-dose IL-2 (ldIL-2) therapy in RA, and determine the prospects for Treg-selective IL-2-based agent…
The therapeutic potential of the IL-2-Treg axis in rheumatoid arthritis
Objective. To summarize data on the role of interleukin-2 (IL-2) in the immunopathogenesis of rheumatoid arthritis (RA), evaluate the clinical experience with low-dose IL-2 (ldIL-2) therapy in RA, and determine the prospects for Treg-selective IL-2-based agent…
Sorcin is a potential molecular target for aimed pharmacotherapy of bronchial asthma and chronic obstructive pulmonary disease
Introduction. Sorcin is a protein that regulates calcium concentration in the endoplasmic reticulum in normal and cancer cells. The role of sorcin in the pathogenesis of oncological diseases is well known. However, its role in ontogenesis and development of br…
ESAT-6 and CFP-10 in tuberculosis immunodiagnostics: molecular and pathogenetic basis, diagnostic potential and limitations
Relevance. Tuberculosis immunodiagnostics is based on the ESAT-6 and CFP-10 antigens (RD1 region of Mycobacterium tuberculosis), which are absent from BCG strains and form the antigenic basis of IGRA and TBST. Their clinical use requires consideration of sever…
Cell redox status and the effectiveness of RNA-inducers of interferon: the role of the glutathione system, mitochondrial signaling and ascorbate-dependent mechanisms in personalized immunomodulation
Introduction. The efficacy of RNA interferon inducers depends not only on ligand structure and innate immune receptor engagement but also on the metabolic state of the target cell. Increasing evidence indicates that redox homeostasis, glutathione system parame…
Molecular regulation of bone remodeling during the menopause transition
Objective. To relate hormonal, osteoimmune, and metabolic regulation of bone remodeling during the menopause transition to clinical evidence. Material and methods. A narrative analysis covered publications identified through PubMed and journal and professional…
Leiomyomas of various locations: current concepts of pathogenesis
Material and methods. A literature search was conducted in the PubMed/MEDLINE, Web of Science, Scopus, eLibrary.Ru, and Google Scholar for the period from 2022 to 2026. The search string included the following keywords: “leiomyoma”, “uterine leiomyoma”, “fibro…
MOLECULAR PATHWAYS OF MACROPHAGE POLARIZATION
Introduction. Macrophage polarization is a key mechanism of immune regulation that determines their functional plasticity. Depending on the microenvironment, macrophages differentiate into proinflammatory (M1, activated by IFN-γ and LPS) or anti-inflammatory (…
Oxidation-reduction mechanisms of action and selection criteria for anticancer selenium compounds
Introduction. The antitumor effects of selenium compounds depend on their structure and biotransformation. Toxic metabolite formation may coexist with enhanced selenoprotein-mediated protection of tumor cells; chemical reactivity does not establish therapeutic…
Molecular mechanisms of clinical heterogeneity in primary dysmenorrhea
Aim. To relate data on the molecular mechanisms of primary dysmenorrhea to the main dimensions of its clinical heterogeneity: pain severity and duration, systemic symptoms, response to nonsteroidal anti-inflammatory drugs (NSAIDs), and propensity to chronic pa…