Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Molecular aspects of improving physical performance in conditions of short-term hypobaric hypoxia and pharmacological pseudohypoxia
Background. Hypoxic training are actively used in both professional and amateur sports. Hypoxia triggers a number of adaptive mechanisms aimed at improving stamina. However, these compensatory and adaptive pathways can be activated through rational pharmacolog…
Relationships between growth factors and clinical diagnostic parameters in patients with diabetic foot syndrome
Aim of the study was to establish the relationships between vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF-BB), and transforming growth factor β1 (TGFβ1) and clinical diagnostic parameters in patients with diabetic foot syndrom…
Modeling of metabolic syndrome in mice and its pharmacological correction
Introduction. Metabolic syndrome is a cluster of interrelated disorders of carbohydrate and lipid metabolism and requires reproducible experimental models suitable for pharmacological screening. Long-term exposure of laboratory animals to high-calorie diets ca…
Holistic multiprofile model of cardiometabolic risk: from preclinical phenotyping to structural and functional damage to the heart and blood vessels
Introduction. Non-communicable diseases develop long before clinical manifestation, and their subclinical signs may be missed by one-dimensional risk assessment. A holistic multiprofile approach combining somatic, psychoemotional and behavioural determinants m…
The effect of GHK-PGP peptide and its analogues on the rat’s behavior in the forced swimming test
Introduction. The Gly-His-Lys (GHK) peptide, which is a fragment of type I collagen, has a wide range of biological effects, including neurotropic ones, and has an anxiolytic and analgesic effect. However, GHK is susceptible to proteases and various proline-co…
SNCA long 3’UTR transcripts in patients with synucleinopathy
Introduction. Post-transcriptional and post-translational modifications of the alpha-synuclein protein are considered important links in the pathogenesis of Parkinson’s disease (PD) and multiple system atrophy (MSA). Regulation of mRNA stability and translatio…
Effect of phytocomposition based on B. vulgaris, C. bergamia, D. villosa and L. meyenii on the state of the germinal epithelium of rat testes on a high-fat diet
Introduction. Plant biologically active compounds are considered as potential means of correcting reproductive function in obesity, but the molecular and cellular mechanisms of their action remain poorly understood. The purpose of the study. To study the effec…
Artificial intelligence and multimodal phenotyping of obesity: a path toward personalized molecular medicine
Introduction. Body mass index remains a convenient screening tool but fails to capture fat distribution, body composition, molecular inflammatory status, psychobehavioral features, or obesity-related end-organ dysfunction. Objective. To develop and substantiat…
ОБЗОРЫ
Spatial analysis of tissue microenvironment functional morphology: multidimensional visualization techniques and artificial intelligence
Objective. To systematically categorize contemporary approaches and technologies for visualizing structural components of the tissue microenvironment (TME), with a focus on the advantages, limitations, and data analysis strategies of multiplex immunohistochemi…
Absence of muscle atrophy in some rheumatic diseases: fundamental and applied aspects of paradoxical preservation of inflammatory muscles
Introduction. Although chronic inflammation is typically associated with tissue catabolism and wasting, most autoimmune rheumatic diseases, including polymyositis, dermatomyositis, lupus myositis, and overlap myopathies, as a rule paradoxically display preserv…
Metabolic pathways and systemic significance of iron-regulating molecules in microorganisms
The review aims at analyzing the present-day knowledge of iron-regulating molecules in microorganisms: their synthesis, secretion, the transport systems that facilitate iron uptake into the cell, the role of these molecules in the development of pathological p…
Alpha-Synuclein: from structural biology and conformational dynamics to molecular mechanisms of neurotoxicity
Objective. To systematize current knowledge on the structural organization, conformational dynamics, and mechanisms of membrane toxicity of alpha-synuclein, as well as to analyze the role of age-associated impairment of proteostasis systems in the pathogenesis…
Transformation of spiral arteries during pregnancy: pathogenic parallels between preeclampsia and placenta accrete spectrum
Introduction. Spiral artery transformation is a key physiological process of pregnancy that establishes low-resistance uteroplacental blood flow. It involves trophoblast invasion of the vascular wall, replacement of the endothelium, and disruption of the smoot…
Antigen-specific skin tests for detecting tuberculosis infection before biologic and targeted therapy: molecular and immunological foundations and clinical interpretation
Introduction. The expanding use of biologic agents, targeted synthetic drugs, and other immunosuppressive treatments has increased the importance of testing for tuberculosis infection in patients at risk of developing tuberculosis disease. Mycobacterium tuberc…
Interferon signature as a tool for stratifying response to immunomodulatory complexes of yeast RNA and ascorbic acid: molecular markers and prospects for personalized application
Introduction. Immunomodulatory complexes based on yeast RNA and ascorbic acid are regarded as a natural multitarget platform capable of affecting innate immune receptors, interferon signaling and cellular redox balance. However, variability of the interferon r…