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Molecular Medicine
Objective. To systematically categorize contemporary approaches and technologies for visualizing structural components of the tissue microenvironment (TME), with a focus on the advantages, limitations, and data analysis strategies of multiplex immunohistochemi…
Introduction. Body mass index remains a convenient screening tool but fails to capture fat distribution, body composition, molecular inflammatory status, psychobehavioral features, or obesity-related end-organ dysfunction. Objective. To develop and substantiat…
Introduction. Plant biologically active compounds are considered as potential means of correcting reproductive function in obesity, but the molecular and cellular mechanisms of their action remain poorly understood. The purpose of the study. To study the effec…
Introduction. Post-transcriptional and post-translational modifications of the alpha-synuclein protein are considered important links in the pathogenesis of Parkinson’s disease (PD) and multiple system atrophy (MSA). Regulation of mRNA stability and translatio…
Introduction. The Gly-His-Lys (GHK) peptide, which is a fragment of type I collagen, has a wide range of biological effects, including neurotropic ones, and has an anxiolytic and analgesic effect. However, GHK is susceptible to proteases and various proline-co…
Introduction. Non-communicable diseases develop long before clinical manifestation, and their subclinical signs may be missed by one-dimensional risk assessment. A holistic multiprofile approach combining somatic, psychoemotional and behavioural determinants m…
Introduction. Metabolic syndrome is a cluster of interrelated disorders of carbohydrate and lipid metabolism and requires reproducible experimental models suitable for pharmacological screening. Long-term exposure of laboratory animals to high-calorie diets ca…
Aim of the study was to establish the relationships between vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF-BB), and transforming growth factor β1 (TGFβ1) and clinical diagnostic parameters in patients with diabetic foot syndrom…
Introduction. Cerebrovascular diseases are a heterogeneous group of conditions shaped by the interaction of polygenic susceptibility, rare monogenic variants, vascular remodeling, neuroinflammation, dysregulated hemostasis, and epigenetic reprogramming. Recent…
Introduction. Single-stranded yeast RNA–ascorbic acid complexes are of interest as a class of natural immunomodulatory systems combining activation of innate immune pattern-recognition receptors with redox-modulating and epigenetic effects of vitamin C. Russia…
Introduction. An aortic aneurysm is defined as an irreversible progressive enlargement of the aorta with an increasing risk of rupture, often fatal. It is known that the imbalance of inhibitors and activators of cell matrix proteolysis and the death of smooth …
The aim of this review is to analyze current understanding of the molecular mechanisms of altered sensitivity of the arterial baroreflex and peripheral chemoreflex and their potential association with perioperative complications. Material and methods. The revi…