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Molecular Medicine
Introduction. Radiotherapy carries a risk of liver damage: radiation-induced liver disease develops in 5 – 10% of cases after gamma-irradiation at 30 Gy, driven by oxidative stress and depletion of endogenous antioxidant defense. Existing radioprotectors, such…
Introduction. Colorectal cancer (CRC) remains one of the leading oncological diseases, the development of which is accompanied by characteristic epigenetic changes. The most significant of these is the hypermethylation of the SEPT9 gene, detected both in tumor…
Introduction. Despite research into the pathogenesis of depression in PD, there is still no unified theory regarding its onset. Objective: To evaluate the expression of tyrosine hydroxylase (TH) and 3-nitrotyrosine (3-NT) in brain structures using models of PD…
Objective. To assess the association of age, anaemia, impaired renal function and concomitant therapy with direct oral anticoagulant (DOAC)-related outcomes in patients aged 60 years and older with multimorbidity and polypharmacy. Material and methods. This pr…
Introduction. The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is based on lipid accumulation in hepatocytes accompanied by oxidative stress and the development of steatohepatitis, whereas the etiology of alcoholic liver disease (ALD) is associate…
Background. Hypoxic training are actively used in both professional and amateur sports. Hypoxia triggers a number of adaptive mechanisms aimed at improving stamina. However, these compensatory and adaptive pathways can be activated through rational pharmacolog…
Introduction. Immunomodulatory complexes based on yeast RNA and ascorbic acid are regarded as a natural multitarget platform capable of affecting innate immune receptors, interferon signaling and cellular redox balance. However, variability of the interferon r…
Introduction. The expanding use of biologic agents, targeted synthetic drugs, and other immunosuppressive treatments has increased the importance of testing for tuberculosis infection in patients at risk of developing tuberculosis disease. Mycobacterium tuberc…
Introduction. Spiral artery transformation is a key physiological process of pregnancy that establishes low-resistance uteroplacental blood flow. It involves trophoblast invasion of the vascular wall, replacement of the endothelium, and disruption of the smoot…
Objective. To systematize current knowledge on the structural organization, conformational dynamics, and mechanisms of membrane toxicity of alpha-synuclein, as well as to analyze the role of age-associated impairment of proteostasis systems in the pathogenesis…
The review aims at analyzing the present-day knowledge of iron-regulating molecules in microorganisms: their synthesis, secretion, the transport systems that facilitate iron uptake into the cell, the role of these molecules in the development of pathological p…
Introduction. Although chronic inflammation is typically associated with tissue catabolism and wasting, most autoimmune rheumatic diseases, including polymyositis, dermatomyositis, lupus myositis, and overlap myopathies, as a rule paradoxically display preserv…