Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
CAV1 GENE POLYMORPHISM IN PATIENTS WITH PRIMARY OPEN-ANGLE GLAUCOMA
Introduction. Glaucoma is associated with a progressive decrease of visual functions, leading to blindness. One of the important factors is the outflow of the ocular fluid. А genetic association study has identified a sequence variant at the chromosome 7q31 (r…
EXPRESSION OF INNATE IMMUNE RECEPTORS AND TRANSCRIPTIONAL REGULATION OF T-HELPER CELLS IN EXPERIMENTAL ILEITIS AND CONDUCT OF THE SIMVASTATIN AND ARIL-1
Introduction. The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that the T-helper cells are components of the adaptive immune response whereas Toll-like receptors, NOD-like-receptors, RIG-I-li…
GENERAL AND SPECIFIC IN THE GENOME OF PATIENTS WITH TYPE 1 AND TYPE 2 DIABETES
Introduction. Diabetes mellitus type 1 and type 2 are having a number similar etiological factors and certain resemblance in the mechanisms of the disease. Therefore it is important to try to estimate the role of common genetic component in the genesis and for…
EVOLUTIONARY SIGNIFICANCE OF NON-SYNONYMOUS SUBSTITUTIONS FOR MYCOBACTERIUM TUBERCULOSIS OF URAL GENOTYPE
Introduction. Russian population of Mycobacterium tuberculosis includes both highly virulent and less virulent strains; the Ural genotype makes an example of the latters. The aim of study was investigation of the most significant synonymous and non-synonymous …
TRANSFORMING GROWTH FACTOR-Β1,2,3 AND INTERLEUKIN-6 IN BLOOD IN PATIENTS WITH ULCERATIVE COLITIS OF VARIOUS DISEASE ACTIVITY ACCORDING TO CLINICAL PICTURE AND ENDOSCOPIC DATA
Introduction. Ulcerative colitis is a chronic inflammatory disease. Misbalance in innate and adaptive immunity including cytokines plays a significant role in its pathogenesis. Objective. To determine levels of cytokine TGFβ1, 2, 3, and IL6 in blood of patient…
MOLECULAR GENETIC MARKERS IN EVALUATING RISK OF OCCUPATIONAL DISEASES AMONG WORKERS IN THE CHEMICAL PRODUCTIONS
Introduction. Determination of the role of genetic markers in the formation of individual susceptibility to the effects of harmful chemicals both opens up new possibilities for assessing the risk of occupational and production-related diseases and address prev…
ОБЗОРЫ
TO THE QUESTION OF USE OF PARAFFIN BLOCKS WITH MALIGNANT TUMORS FOR IDENTIFICATION OF THE GENETIC IDENTITY OF SAMPLES
On the basis of published data there were assessed criteria of eligibility of paraffin blocks with malignant tumors for the decision of a question of the genetic identity of the samples. In order to prevent potential errors it’s not recommended to use the carc…
STAPHYLOCOCCUS AUREUS TOXINS AND TOXOIDS: ROLE IN PATHOGENESIS AND PREVENTION OF STAPHYLOCOCCAL INFECTIONS
Staphylococcus aureus – the pathogenic microorganism that can cause as well hospital as community-acquired diseases. The emergence and subsequent spread of strains resistant to many antimicrobial agents, and, above all, methicillin-hospital strains (HA-MRSA) a…
SOMATIC MUTATIONS ARE THE MAIN EVENTS OF CARCINOGENESIS IN CLEAR CELL RENAL CANCER
Renal cancer is among the most common oncourological diseases, and represents a heterogeneous group of tumors, which up to 80% is a clear cell renal cancer (CCRC). The study of rare hereditary forms of CCRC led to identification of the VHL gene; germinal VHL m…