Table of contents
ОБЗОРЫ
POSSIBLE APPLICATIONS OF UMBILICAL CORD BLOOD HEMATOPOIETIC STEM CELLS WITH CCR5-DELTA 32/DELTA 32 GENOTYPE FOR THE TREATMENT OF HIV INFECTION
Introduction. Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the cell membrane initiates the viral entry process. Simultaneous expression of these two receptors has been observed on T-lymphocytes, mon…
MOLECULAR MECHANISMS OF ACTION OF PROGESTERONE IN THE ENDOMETRIUM
The problem of the treatment of hyperplastic diseases of endometrium currently remains to be a matter of interest. Existing methods of hormone therapy fail to differ in high efficacy. Authors tried to find out reasons for the lack of success of hormonal manage…
MOLECULAR BIOLOGY OF LOW-GRADE MALIGNANCY GLIOMAS IN CHILDREN
The literature review provides information on the molecular biology of low-grade malignancy gliomas (LGMG) in children and adolescents. The data on specific genetic aberrations in pilocytic astrocytoma, pleomorphic xantoastrocytoma, subependimal giant cell ast…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
INFLUENCE OF AFOBAZOL ON THE LEVEL OF INDUCIBLE NO-SYNTHASE IN ISCHEMIC MYOCARDIUM
The purpose of this study. Evaluation the effect of Afobazol on the level of myocardial inducible NO-synthase (iNOS) in the ischemic myocardium in rats. Methods. Myocardial ischemia was produced by the Selye’s method. The of inducible NO-synthase level on the …
THE INFLUENCE OF FUNCTIONAL POLYMORPHISM IN THE GALANIN PROMOTOR ON GLATIRAMER ACETATE EFFICACY IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
Introduction. Glatiramer acetate (GA, copaxone) – is an immunomodulatory drug, used for reducing the progression of multiple sclerosis. The absence of optimal therapeutic effect in some cases determines the necessity to search the prognostic markers of GA effi…
MOLECULAR AND CELLULAR FACTORS OF LOCAL IMMUNITY IN ASCITIC FLUID OF OVARIAN CANCER PATIENTS
Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …
INFLUENCE OF THE EXPRESSION OF E7 PROTEIN ON GROWTH FACTORS AND MARKER OF SQUAMOUS CELL CARCINOMA SСC IN THE TISSUE OF CERVICAL CANCER
Introduction. Study of growth factors content in tumors of different localizations and assessment of their probable correlation with the main clinical and morphological characteristics are relevant nowadays. Products of expression of the viral genome – E7 and …
METHODICAL ASPECTS OF USING RAT RBL-2H3 BASOPHILS FOR DEGRANULATION STUDY
Introduction. Mediator release from mast cells or basophils is the key event in many acute allergic and inflammatory processes. Rat basophilic leukemia cell line RBL-2H3 cells is widely used as a model for studying mast cells degranulation. Aim of the study. T…
SIGNIFICANCE OF EXPRESSION OF MOLECULAR MARKERS IN DIAGNOSTICS OF PRECANCEROUS LESIONS AND TRANSFORMATIONS OF GASTRIC MUCOSA
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…
GENETIC AND MORPHOLOGICAL MARKERS OF NON-DEVELEPING PREGNANCY
Introduction. High rate of non-developing pregnancy in the structure of reproductive loss dictates the need to identify the etiological factors of this disease at different levels of organization of alive matter. The aim of the study. The search for associatio…