Table of contents
ОБЗОРЫ
STEROID SENSITIVITY IN BRONCHIAL ASTHMA
The main purpose of the treatment of bronchial asthma is achievement and maintenance of the control over the symptoms of disease at optimal level. For this purpose in terms of basic therapy there is used inhalation of as glucocorticosteroids as well systemic g…
MODERN POSSIBILITIES OF MOLECULAR ONCOLOGY: CIRCULATING TUMOR CELLS
The purpose of the study was to analyze publications on circulating tumor cells and to conduct our own research. Detection of circulating tumor cells was made in 60 patients with colorectal cancer and resectable metastatic liver lesion Т2-4N0-1M1 on the tenth …
TRANSLATIONAL AND POST-TRANSLATIONALREGULATION OF ACTIVITY OF HIF-1 IN HYPOXIA AND ISCHEMIA
This review covers current concepts on the structure, function, regulation of translation and post-translational modifications of hypoxiainducible factor 1 (HIF-1). In addition, the role of this transcription factor in hypoxia and ischemia is discussed. We foc…
GENETIC PREDICTORS OF THE DEVELOPMENT OF RETINAL VESSELS OCCLUSION
Retinal vascular occlusion is one of the most severe vascular lesions of the eye, leading to permanent disability. Approximately 16 million adults in the world have this pathology at the age over 40 years. Typically, the disease occurs acutely as a result of m…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
SEX HORMONES AS REGULATORS OF THE LEVEL OF GROWTH FACTORS IN TUMOR TISSUES IN POLYNEOPLASIA OF FEMALE REPRODUCTIVE ORGANS
Introduction. Sex hormones are known to influence on synthesis of growth factors in breast and uterus tumors, but their correlation in polyneoplasias is poorly studied. The aim of the study. The analyze local steroidogenesis, synthesis of growth factors and th…
GENETIC POLYMORPHISM OF TOLL-RECEPTORS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C OF TRANSBAIKALIAN REGION
Introduction. Currently, in the pathogenesis of various diseases have been intensively studied the structure and function of innate immune receptors, a special role played by a Toll-like receptors (TLR). In the recent literature there are no comprehensive stud…
TNF GENE POLYMORPHISMS AFFECT THE PROGRESSION OF THE DISEASE IN BREAST CANCER PATIENTS
Introduction. Tumor necrosis factor (TNF) plays a central role in the development of inflammatory and neoplastic processes. In the TNF gene promoter region there are -308(g/a) and -238(G/A) polymorphisms with different influence on the level of expression of T…
ASSOCIATION BETWEEN XRCC1 ARG399GLN AND P53 ARG72PRO POLYMORPHIC MARKERS AND THE RISK OF BREAST CANCER RISK IN KYRGYZ WOMEN
Aim. To investigate the possible association between XRCC1 Arg399Gln and p53 Arg72Pro polymorphism and the risk of breast cancer (BC) risk in Kyrgyz women. Methods. The XRCC1 Arg399Gln and p53 Arg72Pro genotypes were determined with the use of the polymerase c…
POLYMORPHISM ANALYSIS OF THE ACTA2 GENE BY PYROSEQUENCING IN PATIENTS WITH NON-FAMILIAL THORACIC AORTIC ANEURYSMS
Introduction. The ACTA2 gene encodes α-actin in aortic smooth muscle cells, and its mutations may cause thoracic aortic aneurysms. Analysis of ACTA2 polymorphism can be used in a complex risk assessment of non-familial thoracic aortic aneurysms. The aim of the…
ANALYSIS OF THE ASSOCIATION BETWEEN AIR POLLUTION AND THE DEVELOPMENT OF LARYNGOTRACHEITIS IN CHILDREN
Introduction. Ambient air pollution is important worldwide problem. Numerous studies have found associations between air pollution and respiratory diseases, cardiovascular diseases, diabetes, and infant mortality. Children are more susceptible to the air pollu…
EVALUATION OF OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY IN PATIENTS WITH CORONARY ATHEROSCLEROSIS
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
EFFECTS OF CHLORPROMAZINE ON THE N-METHYL-D-ASPARTATE DEPENDENT MECHANISMS OF LONG-TERM POST-TETANIC POTENTIATION FOR UNDERSTANDING OF MENTAL DISORDERS
Introduction. Clinical observations have revealed that the treatment of schizophrenia with the use of chlorpromazine (CPZ) impairs cognitive processes. Whether it is possible to eliminate these side effects of CPZ? The aim of the study. The aim of our study wa…