Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
MOLECULAR-GENETIC CHARACTERISTICS OF EARLY RHEUMATOID ARTHRITIS
Objective. To study the distribution of PTPN22, TNFAIP3, CTLA4, TNFA, IL-6, IL-6R, IL-10, MCP-1, ICAM1 alleles and genotypes in early rheumatoid arthritis (eRA) patients and controls, and assess their value as potential molecular-genetic markers of predisposit…
INFLUENCE OF NITRIC OXIDE SPATIO TEMPORAL CONCENTRATION GRADIENTS ON CONDITIONS OF HYPOXIA DEVELOPMENT IN TISSUES
Introduction. Nitric oxide is a well-known regulator of different metabolic processes in cells and tissues. Its effect is usually represented as a balanced combination of both mediator and toxic action and the mutual ranges of them are not simply identified. I…
RELATIONSHIP OF PLOIDITY AND LOCAL IMMUNITY IN TUMORS OF THE COLON
Introduction. The biologic behaviour of the tumor can be determined by both its own characteristics including ploidity of the tumor cells and peculiarities of its lymphocytic and cytokine microenvironment, in particular. The aim of the study. To perform a comp…
TO THE MECHANISM OF MYOCARDIAL REMODELING IN THE ACUTEST PHASE OF EXPERIMENTAL MYOCARDIAL INFARCTION
The purpose of research. The study of the features of the left ventricle remodeling in the acutest stage of experimental myocardial infarction and the possibility of the correction of detected injuries. Methods. Experimental myocardial infarction in rats was i…
RANK/RANKL/OPG SYSTEM COMPONENTS AND INTERLEUKINS 6, 8 16 IN BLOOD SERUM OF PATIENTS WITH PRIMARY BONE NEOPLASMS
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…
INFECTIOUS AGENTS AS MODIFYING FACTORS OF DE NOVO HORMONE SYNTHESIS IN TUMOR TISSUE IN PATIENTS WITH UTERINE CARCINOMA
Introduction. The influence of widespread, often long-lasting infections like herpes simplex virus (HSV), cytomegalovirus (CMV) and chlamydia infections on endocrine profile in organs of reproductive system and the role of infections in pathogenesis of uterine…
MOLECULAR ASPECTS OF CHRONIC ENDOMETRITIS IN FEMALES OF VARIOUS AGE GROUPS
Introduction. Endometritis and elder fertile age are the one of the main reason of infertility. Molecular methods of endometrial investigation have opened new perspectives in diagnostics and evaluation of the efficacy of the management of endometritis Objectiv…
GENE SLCO1B1 ASSOCIATED WITH STATIN-INDUCED MYOPATHY IN RUSSIAN AND SAKHA (YAKUTIA) STATIN INTAKE PATIENTS SUFFERED FROM HYPERLIPIDEMIA
Introduction. SLCO1B1 encodes the organic anion-transporting polypeptide which has been shown to regulate the hepatic uptake of statins. SLCO1B1*5 genetic variant is associated with the high risk for statin-induced myopathy in patients with statins therapy. Ai…
NON-PEPTIDE ANALOGUE OF A FRAGMENT OF SOLUBLE ABETA PRECUSOR PROTEIN POTENTIATES WEAK MEMORY AND C-FOS EXPRESSION IN THE MOUSE BRAIN
Introduction. Short-term and long-term memory impairments are the main symptoms of several socially important neurodegenerative disorders, such as Alzheimer disease. For this purpose the pharmacological enhancement of short-term memory is of great interest. No…
ОБЗОРЫ
INHIBITORS OF CARBOHYDRATE METABOLISM IN CANCER THERAPY
Energy supply of cells can be provided through both an oxygen-dependent pathway of mitochondrial oxidative phosphorylation and oxygenindependent glycolysis. Oxidative phosphorylation in the synthesis of ATP is more efficient than in glycolysis, and respectivel…
FACTORS OF HEREDITARY PREDISPOSITION FOR PREECLAMPSIA: GENERALIZATION OF DATA OF META-ANALYSES
Preeclampsia is the pregnancy complication characterized by the presence of arterial hypertension and proteinuria. Preeclampsia is the leading cause of maternal and perinatal morbidity and mortality. To date, there are more than 40 advanced theories of etiopat…