Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF MODERN HETEROMEROUS PEPTIDES WITH IMIDAZO[4,5-Е]BENZO[1,2-C;3,4-C’]DIFUROXAN FRAGMENT AS NEW INHIBITORS OF PLATELET AGGREGATION
Introduction. Cardiovascular diseases consistently occupy the first place among causes of death and disability in almost all developed countries. The main importance of this group of diseases have myocardial infarction. One of the causes of myocardial infarcti…
CONCENTRATION OF INTERLEUKINES IN BLOOD PLASMA IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA – CARRIERS OF ANTI-INFLAMMATORY CYTOKINES GENES POLYMORPHISMS
Introduction. There were examined 195 patients with chronic сerebrovasсular pathology and 149 healthy residents of the Zabaykalsky region. The aim of the study. Detection of genetic polymorphism in cytokines IL4-589С>T, IL10-1082G>A, IL10-819C>T, IL10-592C>A, …
INFLUENCE OF CYTOTOXIC CHEMOTHERAPY ON THE ERCC1, XPD AND DPYD EXPRESSION IN COLORECTAL CANCER LIVER METASTASES
Introduction. The elevated expression of components of DNA repair system ERCC1 (excision repair cross-complementing group 1) and XPD (Xeroderma pigmentosum group D) is associated with the lack of efficacy of DNA–damaging cytotoxic platinum-based preparations. …
STABILIZATION OF HUMAN PLATELETS ON THE ADHESIVE SUBSTRATE WITH USE OF TICAGRELOR
Introduction. Producing of combined biotransplants with human platelets may be accompanied by high rate of the loss of biological active platelet components. It is suggested to use blockers of platelet activity to fix these cells on adhesive substrate surface.…
ASSOCIATION OF CANCER MOLECULAR PARAMETERS WITH EFFECTIVENESS OF PAZOPANIB TREATMENT IN ADVANCED KIDNEY CANCER PATIENTS
Introduction. The search for criteria for the prediction of the efficacy of targeted therapies will allow not only to optimize the readings, but also to improve the results of treatment of patients with metastatic kidney cancer. The aim of the study is the inv…
THE SPONTANEOUS DELIVERY AFTER CORRECTION OF HYDROMETRA BY ADMINISTRATION OF MULTIPOTENT MESENCHYMAL STROMAL CELLS IN EXPERIMENT
Introduction. The angiogenesis in a uterus scar after application of multipotent mesenchymal stromal cells of a bone marrow origin (MMSCBM) was shown. However, possibility of approach of pregnancy and spontaneous deliveries in rats after MMSCBM introduction in…
ТР53 GENE MUTATIONS AND THEIR PROGNOSTIC SIGNIFICANCE IN BLADDER CANCER
Introduction. Mutations in the tumor suppressor gene TP53 are observed approximately in the half of all human malignancies. In bladder cancer (BC), ТР53 molecular alterations were shown to be associated with more aggressive tumor phenotype; however their clini…
GE-ASSOSIATED ASPECTS OF THE EXPRESSION OF HUMAN ENDOTHELIAL SIGNAING MOLECULES AND THEIR ROLE IN THE DEVELOPMENT OF CARDIO-VASCULAR PATHOLOGY
Introduction. Age-assosiated endothelial changes are one of the reasons of the development of cardio-vascular pathology. Moreover, molecular mechanisms of human endothelium aging are investigated only slightly. Thus, the problem of pathogenesis of cardio-vascu…
INSULIN-LIKE GROWTH FACTORS AND SEX HORMONES IN TUMOR TISSUE IN POLYNEOPLASIAS OF FEMALE REPRODUCTIVE ORGANS
Introduction. IGF-1R in breast cancer tumor tissue was shown to be expressed in large quantities in comparison with benign tumor or normal breast tissue. At the same time, IGF-1 stimulates proliferation of normal and tumor breast cells. The aim of the study. T…
APOPTOSIS INHIBITOR GENES AS A TARGET OF ANTICANCER THERAPY AND PROGNOSTIC MARKERS
Genes encoding proteins of IAP (Inhibitor of apoptosis proteins) have increased expression in the cells of malignant tumors of different localizations. IAPs perform several functions related to the viability of cancer cells and their subsequent proliferation. …
THE EFFICACY AND SAFETY OF DIINDOLYLMETHANE IN THE VAGINAL SUPPOSITORY DOSAGE FORM IN THE TREATMENT OF CERVICAL INTRAEPITHELIAL NEOPLASIA
The aim of the study. The clinical study of the efficacy and safety of the novel pharmaceutical composition Cervicon-DIM on the base of diindolylmethane (DIM) in vaginal suppository form in the course of the conservative treatment of cervical intraepithelial n…
ОБЗОРЫ
RECOMBINANT BLOOD COAGULATION FACTORS: STRUCTURE FEATURES AND QUALITY ASSESSMENT
The review is devoted to problems of quality assessment of recombinant coagulation factors approved in the Russian Federation. The list of recombinant blood coagulation factor products approved in the world was provided. Benefits of the use of recombinant bloo…