Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
ASSOCIATIONS OF CANDIDATE GENES IN THE FORMATION OF UTERINE FIBROIDS
Introduction. Uterine fibroids – a benign tumor, growing from immature muscle cells of the vascular wall of the uterus. It ranked first among the benign tumors of the genital organs, with one in ten suffers from gynecological patients with uterine myoma. The a…
REGULATORY HIF CASCADE IN EPIDERMAL KERATINOCYTES: DYNAMICS OF ACTIVITY AND DEPENDENCE ON HYPOXIA
Introduction. The transcriptional activity of hypoxia-inducible factor 1 (HIF1) not only drives cellular adaptation to O2 deficiency, but also plays an important role in the development and functioning of various organs and tissues. Data on the role of HIF reg…
THE ROLE OF ANTIMICROBIAL PEPTIDES IN SHAPING OF MICROBIOCENOSIS OF FEMALE REPRODUCTIVE TRACT AT LATE PREGNANCY
Introduction. Antimicrobial peptides (AMPs) are molecules of small dimensions, consisting of about 30–40 amino acids, possessing of antiviral, antibacterial and fungicidal action. AMPs can be considered as a first barrier against pathogens in genital tract. Th…
MOLECULAR GENETIC AND PHENOTYPIC CHARACTERISTICS OF PATIENTS WITH LUNG ADENOCARCINOMA AMONG INHABITANTS OF THE SOUTH OF RUSSIA
Introduction. EGFR mutation and EML4-ALK fusion are the most clinically significant genetic alterations in non-small cell lung cancer. Numerous studies have been devoted to EGFR mutations and their association with phenotypic clinical and pathological characte…
A SEARCH FOR MARKERS OF GENETIC SUSCEPTIBILITY TO THE DEVELOPMENT OF JOINT HYPERMOBILITY AND OSTEOARTHRITIS IN PATIENTS FROM THE BASHKORTOSTAN REPUBLIC
Introduction. Osteoartitis (OA) is the polyetiological disease pathogenesis of which is not fully understood. One of the risk factors for osteoarthritis may be connective tissue dysplasia, which is based on genetic defects of cartilage structures. The aim is t…
ПЕРЕДОВАЯ СТАТЬЯ
MOLECULAR AND CELLULAR MECHANISMS OF ALZHEIMER’S DISEASE
Alzheimer's disease being the socially significant neurodegenerative disease of the elderly, ranks 6th on the causes of death among somatic pathologies. The molecular mechanisms of Alzheimer's disease still remain unexplored until the end, and the efficacy of …
ОБЗОРЫ
COMMON DISEASE: ROLE OF GENETIC FACTORS AND NUTRIENTS
In this brief review there are considered possible reasons for the spread of disease of the multifactorial nature in modern populations from standpoints of the discordance between evolutionary formed genetic diversity and rapidly changing environmental factors…
PEPTIDE SEQUENCES MIMICKING THE EXTRACELLULAR MATRIX AS A PROMISING OPTION FOR BIOFUNCTIONALIZATION OF CARDIOVASCULAR GRAFTS
Early endothelialization of the inner surface of cardiovascular grafts is imperative for achieving successful functioning in the body. Biofunctionalization of synthetic materials allows to create biomimetic surfaces by incorporating bioactive molecules capable…
PHARMACOGENETIC ASPECTS OF THE EFFICACY AND SAFETY OF HALOPERIDOL IN PATIENTS WITH ADDICTIVE DISORDERS
The use of haloperidol in clinical practice is often accompanied by the development of severe unwanted adverse side effects from the side of various organs and systems. In the narcological practice the use of antipsychotic drugs is not seldom complicated by ex…