Table of contents
ПЕРЕДОВАЯ СТАТЬЯ
THE ROLE OF HUMAN TELOMERASE CATALYTIC SUBUNIT HTERT IN PHYSIOLOGICAL AND PATHOLOGICAL CELLULAR PROCESSES
Telomerase catalytic subunit hTERT is tightly regulated both at the transcriptional and posttranscriptional levels. One of the regulatory mechanisms is its mRNA alternative splicing. Only full-length form has catalytic activity and the ability to elongate telo…
ОБЗОРЫ
THE ROLE OF MESENCHYMAL STEM CELLS SECRETING CYTOKINES IN THE STIMULATION OF THE REGENERATION PROCESSES IN THE BRAIN
The review deals with the analysis of experimental results relating to the protective effect of mesenchymal stem cells (MSCs) after the brain damage. We consider two mechanisms of the MSCs action. The first proposed mechanism is associated with the ability of …
THE ROLE OF MICRORNAS IN THE REGULATION OF MELANOMA SIGNALING PATHWAYS
The frequency of reported cases of melanoma and related mortality rates continue to increase worldwide. The study of the basic mechanisms of both the initiation and development of this highly aggressive tumour proves to be important for the identification of t…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
AΒ42 – APROMISSING NON-INVASIVE MARKER FOR LIFE-TIME DIAGNOSIS OF ALZHEIMER’S DISEASE
Introduction. Alzheimer's disease (AD) is a socially important neurodegenerative disease. The prevalence rate of AD is increasing over recent years. According to the hypothesis concerning AD to be a systematic disease its manifestation can be detected in vario…
DELIVERY OF MITOMYCIN C AND PROLONGATION OF ITS ACTION OWING TO THE USУ OF NEW HYDROGELS OF HYALURONIC ACID AND CHITOSAN SUCCINATE FOR GLAUCOMA SURGERY
Purpose an experimental evaluation of the effectiveness of new hydrogels based on hyaluronic acid and chitosan succinate as an agent of mitomycin C (MMC) for glaucoma surgery. Material and methods. Synthesis of hydrogel drainage (HD): The required amount of MM…
ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH RISK OF CORONARY ARTERY DISEASE IN RUSSIAN POPULATION
Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 …
TWO NOVEL MUTATIONS IN THE SLC37A4 GENE IN A CHILD WITH GLYCOGEN STORAGE DISEASE TYPE IB
Introduction. Glycogen storage disease (GSD) type Ib is caused by mutations in the SLC37A4 gene. The aim of the study. To verify the diagnosis by molecular genetic studies. Patient. Child at the age of 5 years and 8 months with severe hepatomegaly, nephromegal…
DYNAMICS OF THE NUMBER OF M2 MACROPHAGES IN LIVER REGENERATION IN RATS
Introduction. Macrophages are referred to the one of the major cell types that organize the liver regeneration. Macrophages are a heterogeneous cell population. The study of regulatory mechanisms of liver regeneration after subtotal liver resection in rats, co…
THE PROFILE OF MICRORNA EXPRESSION IN LIVER IN CHRONIC HEPATITIS C PATIENTS AND THEIR ASSOCIATION WITH CLINICAL PARAMETERS
Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…
POLYMORPHISM VARIANTS IN NOTCH1 AS PREDICTORS OF AORTIC INSUFFICIENCY IN PATIENTS WITH BICUSPID AORTIC VALVE
The aim of the study was to establish the contribution of NOTCH1 polymorphisms on the development of a combined bicuspid aortic valve and aortic coarctation. Design and Patients. The study included 34 patients, the control group consisted of 200 cases without …
POLYMORPHISM OF UGT1A1 GENE IN PATIENTS WITH COLORECTAL CANCER OF THE SOUTH OF RUSSIA: RESULTS OF PILOT RESEARCH
Introduction. Irinotekan is widely used in the treatment of oncological diseases and allows to achieve the objective answer in 35–70% of cases depending on the applied schedule of the treatment. Individual toxicity of a preparation for patients is determined b…