Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
ABERRANT METHYLATION OF PROMOTER REGIONS OF SOX7, P15INK4B AND WNT PATHWAY ANTAGONIST GENES IN PATIENTS WITH MYELODYSPLASTIC SYNDROME
Introduction. Hypermethylation of CpG islands in tumor-suppressor genes are supposed to be a key mechanism of the development of the myelodysplastic syndrome (MDS) The aim of the study. To determine the association between methylation status of SOX7, p15INK4b,…
PROTEOMIC AND METABOLOMIC MANIFESTATIONS OF DIFFERENT VARIANTS OF APOLIPOPROTEIN E GENES POLYMORPHISM IN OBESE PATIENTS
Introduction. Currently questions on the role of genes polymorphism that regulate metabolism and implicated in metabolic disorders are disputed. Objective. The study of proteomic and metabolomic manifestations of different variants of apolipoprotein E genes po…
ASSOCIATION OF ADRENERGIC RECEPTORS GENES POLYMORPHISMS (ADRA2A, ADRB3) WITH OBESITY IN TATARS WOMEN
Association of adrenergic receptors gene polymorphisms in overweight persons has been shown by Gagnon J. et al. in 1996. For the locus Trp64Arg (rs4994) β3-adrenoceptor gene was shown to be associated with the risk of obesity, confirmed by the works of a numbe…
CONFOCAL LASER SCANNING MICROSCOPY. THE VERIFICATION OF RECEPTORS EXPRESSION OF ESTROGEN AND PROGESTERONE DURING THE MENSTRUAL CYCLE
The study of estrogen and progesterone receptors expression remains to be the one of the major challenges in contemporary gynecology due to the high frequency of the occurrence of infertility, miscarriage and ineffective IVF cycles, hyperplasia and endometrial…
ANALYSIS OF THE INTERFERONS OF I, II AND III TYPES, IL23 AND ANTIVIRAL PROTEIN MXA FOR MULTIPLE SCLEROSIS
Introduction. A lot of factors of innate and specific immunity are involved in development of the autoimmune diseases – multiple sclerosis (MS) that cause the damages of myelin envelopes of nerve fibres with irreversible neurological consequences. To decrease …
ASSOTIATION OF GENES POLYMORPHISMS OF XENOBIOTICS-METABOLIZING ENZYMES WITH RECURRENT MISCARRIAGE
Introduction. Recurrent miscarriage (RM) – a prevalent pathology in women. However, the mechanisms of its occurrence are studied insufficiently. A genetic factor may be one of the causes of RM in women. The aim of the study was to investigate the association o…
CHARACTERISTICS OF DNA-METHYLATION IN UTERINE FIBROIDS
Introduction authors made an attempt to demonstrate the role of DNA-methylation in pathogenesis of uterine fibroids. The epigenetic aspects based on personal investigations and literary data have been reviewed. The research underlined a perspective of investig…
RADIOLOGY AND MORPHOLOGICAL COMPARISONS AT DIAGNOSTICS OF SPLENIC HAMARTOMA
Objective to analyze own data on diagnostics, morphological verification and treatment of the splenic hamartoma, and compare them with the previous research results. Materials and Methods. More than 300 patients with various focal lesions of the spleen have be…
ОБЗОРЫ
IMPORTANCE OF HEAT SHOCK PROTEINS 70 KDA IN DEVELOPMENT OF ACUTE FOCAL MYOCARDIAL AND CEREBRAL ISCHEMIA
In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. It was shown that under ischemic conditions synthesis stress induced proteins includin…
DEVELOPMENTAL CHANGES OF THE EXPRESSION OF CALCIUM-BINDING PROTEINS IN AUTONOMIC GANGLIONIC NEURONS
Calbindin 28 kDa, calretinin and parvalbumin are referred to calcium-binding proteins which are both widely distributed in the nervous system and selectively expressed in certain population of neurons. These proteins are expressed not only in the central nervo…