Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
CLINICAL SIGNIFICANCE OF GENE CYP2C19 POLYMORPHISM IN STEMI PATIENTS (DATA FROM THE KEMEROVO REGISTRY OF THE ACUTE CORONARY SYNDROME)
Aim is to evaluate distribution and clinical significance of gene CYP2C19 polymorfism in ST-segment elevation myocardial infarction (STEMI) patients. Materials and methods. A total of 159 patients were encluded in this study. All of them underwent primary PCI.…
CONTRACTING CAPACITY OF EMBRYONIC FIBROBLASTS WITH VARIED REGENERATIVE POTENTIAL
Introduction. Contracting deep scars are almost unresponsive to conservative treatment and often require repeated surgical intervention. These scars represent a serious problem in skin therapy after the extensive damage. Just the impairment of processes of the…
STUDYING OF MOLECULAR MECHANISMS OF RESISTANCE OF CORYNEBACTERIUM DIPHTHERIAE STRAINS TO RIFAMPICIN
Introduction. Penicillins and macrolides are applied for the treatment of both diphtheria carriers, in the comprehensive therapy of separate forms of diphtheria, and patients with invasive diseases caused by nontoxigenic C. diphtheriae. In the 1990s there was …
THE PROBLEMS OF BIOCOMPATIBILITY OF TITANIUM AND HAFNIUM NITRIDE-BASED COATING METALLIC IMPLANTS FOR OSTEOSYNTHESIS
Introduction. At the present time the attention to the development of implant coating is growing in the fields of surgery, odontology, traumatology and orthopedy because of its possibility to improve the stability of metal implants on the one hand and to provi…
A COMPREHENSIVE APPROACH TO THE EVALUATION OF PATHOGENIC FACTORS IN BLOOD SAMPLES OF THE «MARS-500» MISSION
Introduction. The project mimicked the conditions of a manned Mars mission during which six volunteers stayed in a closed complex for 520 days. The aim of the study. The main goal of the research was the complex assessment of blood samples of volunteers for th…
OXIDATIVE AND NITROSATIVE STRESSES ON THE TRANSLATIONAL MODEL OF DIABETES; NORMALIZING EFFECT OF PRO-GLY-CONTAINING DIPEPTIDE, NOOPEPT
Introduction. Oxidative and nitrosative stresses are reported to be an important pathogenic factors of diabetes. Taking into account our previous findings that Noopept (N-phenyl-acetyl-L-prolyl-glycine ethyl ester) attenuates the hyperglycemia, decrease of inc…
EXPRESSION OF SIGNAL MOLECULES IN BUCCAL EPITHELIUM IN CHRONIC PARODONTITIS PATIENTS OF THE VARIOUS AGE
Introduction. Significance of chronic parodontitis is determined by not only of the degree of the prevalence rate, severity of the disease, but also by the low efficacy of the treatment and diagnosis at the early stage of disease. Nowadays there are not comple…
ОБЗОРЫ
EXOSOMES FROM VARIOUS BIOLOGICAL FLUIDS: PATTERN AND FUNCTION
Exosomes are microscopic extracellular vesicles with diametr 30–100 nm, which are secreted by different types of cells and may be detected in normal (blood serum, saliva, urine, breast milk) and pathological (ascite) biological fluids. It was shown that exosom…
EFFECT OF HUMAN MICROBIOTA ON THE CARDIOVASCULAR SYSTEM
In the presented review a new potential risk factor for atherosclerosis and cardiovascular disease such as microflora of the human gastrointestinal tract is considered. The modern concept of lipid metabolism and its effects on human health outlining the basic …
APPLICATION OF DRUG CARRIERS FOR DELIVERY OF ANTINEOPLASTIC DRUGS
At present, various antineoplastic agents are widely used to treat cancer. There are certain problems associated with their use, such as the inhibition of the pool of dividing cells, poor tolerance and efficiency. Targeted therapy also has several disadvantage…