Table of contents
ОБЗОРЫ
WHY ADULT BRAIN NEEDS NEW NERVE CELLS?
A half century of studying the neurogenesis of the adult brain has produced much evidence for an endogenous conversion of neural stem cells. Yet the idea receives increasing criticism, in addition to the many positive comments. Does neurogenesis proceed at a r…
THE ROLE OF ADIPOKINES IN PATHOGENESIS OF PERINATAL COMPLICATIONS IN PREGNANT WOMEN WITH DISORDERS OF CARBOHYDRATE METABOLISM
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
LOOP-MEDIATED ISOTHERMAL AMPLIFICATION
This article reviews loop-mediated isothermal amplification (LAMP) technique that since its invention in 2000 has gradually become one of the most popular isothermal amplification technologies. In this paper, we described the mechanism of LAMP reaction, differ…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
CLINICAL IMPLICATION OF SERUM INSULIN-LIKE GROWTH FACTORS (IGF) AND IGF BINDING PROTEINS IN COLORECTAL CANCER PATIENTS
Introduction. Insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignant tumors including colorectal cancer (CRC), so far its components are considered as potential diagnostic and prognostic markers…
EXPRESSION OF THE AGR2 GENE AND ITS ROLE IN THE CONTROL OF THE DEVELOPMENT AND SECRETORY FUNCTION OF MAMMALIAN EPITHELIAL TISSUES
ntroduction. Agr2protein belongs to the family of disulfide isomerases of the endoplasmic reticulum and contains active cysteine domains involved in the formation of disulfide bonds with mucins. It is expressed in goblet cells of the intestinal epithelium and …
EXPRESSION OF ESTROGEN RECEPTORS IN BREAST AS MOLECULAR MARKERS OF PROLIFERATION PROGRESSION
Introduction. Fibroadenomatosis (FAM) is a heterogeneous group of pathological conditions of the mo-Nochnoi gland, with hormone-dependent nature and different degree of risk maligni of the organization. The use of routine histological stains is not enough to d…
CHARCTERISTICS OF CHANGES OF COLLGEN MAIN TYPES I–VI IN CALCIFIC AORTIC VALVE STENOSIS PATHOGENESIS
Introduction. The gain of elderly persons in the population of industrial countries provides a high actuality to investigations of pathogenesis of calcific aortic valve stenosis (CAVS). The aim of the study. To specify the quality and quantity pattern of colla…
TOLL-LIKE RECEPTOR-4 GENETIC POLYMORPHISM IN ERYSIPELAS PATIENTS
Introduction. Erysipelas is characterized by consistently high morbidity rate, pronounced tendency to recur, the frequent change of lymph circulation, formation of secondary elephantiasis and others symptoms. The prediction of the course of erysipelas is unres…
NEW TRANSLATIONAL MODEL OF COGNITIVE DEFICIT IN SCHIZOPHRENIA
Introduction. Taken into account the literature data on the leading role of perceptual deficit in the pathogenesis of schizophrenia and the lack of experimental models of this impairment we proposed the novel test of instinctive aversion (TIA). The work was pe…