Table of contents
ОБЗОРЫ
THE ROLE OF MOLECULAR AND GENETIC FACTORS IN UVEAL MELANOMA PATHOGENESIS
Uveal melanoma (UM) is a rare, aggressive intraocular malignant tumor, leading to metastatic disease in more than 50% of patients. Cytogenetic and molecular studies have identified some genetic prognostic factors considered to be reliable to forecast the survi…
THE INFLUENCE OF NANOPARTICLES ON BIOLOGICAL INTEGRITY OF HUMAN PLATELETS
The review presents data concerning the interaction of basic types of nanoparticles with human platelets in vitro and in vivo and biological results of this influence. The initial structure of nanoparticles and their biologically active cargo can both stimulat…
EXPRESSION OF HUMAN PROTEINS UNDER THE EXTERNAL AND INTERNAL IRRADIATION
The data concerning the changes of expression and posttranslational modification of the human protein under the influence of the external and internal irradiation in vivo and in vitro are presented in this review. The investigation of protein expression and po…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
INVESTIGATION OF THE DISTRIBUTION OF TELOMERASE ACTIVITY IN NODE NEOPLASMAS OF THE THYROID GLAND UNDER PUNCTURE HISTOBIOPSY
Introduction. At the preoperative stage, the leading diagnostic method for nodular thyroid lesions today is a fine-needle aspiration biopsy (FNAB). However the use of FNAB can provide the relatively high portion of poor-information samples (up to 30%) due to t…
MATRIX METALLOPROTEINASE-2 IN BONE MARROW OF PATIENTS WITH ACUTE MYELOID LEUKEMIA AND MYELODISPLASTIC SYNDROME
Introduction. Search for correct markers for diagnosis, prognosis and evaluation of the effectiveness of chemotherapy is the most important problem of the modern oncohematology. The aim. To determine the clinical relevance of matrix metalloproteinase-2 (MMP-2)…
CHARACTERIZATION OF THE MINOR POPULATION OF ACTIVELY PROLIFERATING IN VITRO SERTOLI CELLS FROM THE TRANSITIONAL ZONE OF ADULT MOUSE TESTIS
Introduction. The minor population of Sertoli cells (SCs) from the transitional zone (TZ) of adult mouse testis called as TZ SCs is capable of active proliferation in culture and, at the same time, expresses all key SC markers. It could be an optimal source of…
ACTIVITY OF HIF PATHWAY IN EPIDERMIS AS CONTROL FACTOR FOR SKIN VASCULATURE
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
PLURIHORMONAL CELLS OF ANTERIOR PITUITARY. NEW FEATURES TO OPTIMIZE MOLECULAR DIAGNOSIS OF NEUROENDOCRINE TUMORS
Introduction. Multihormonality is an ability of pituitary cells to produce more than one hormone. A great number of adenomas are multihormonal in the actual practice. We hypothesize cells of a normal pituitary gland to secret several hormones simultaneously. O…
INFLUENCE OF SLCO1B1 GENE C.T521>C POLYMORPHISM ON THERAPY WITH SIMVASTATIN IN CORONARY HEART DISEASE PATIENTS
Introduction. Carrier protein OATP1B1, encoded by the SLCO1B1gene, is involved in the transport of simvastatin into liver cells. SLCO1B1 gene polymorphisms influence on the functionality of the transporter, which could reflect on the efficacy and safety of tre…
OVEREXPRESSION OF APOPTOTIC ENDONUCLEASE ENDOG INHIBITS TELOMERASE ACTIVITY IN HUMAN CD4+ T CELLS
Introduction. Alternative splicing of telomerase catalytic subunit hTERT (human Telomerase Reverse Transcriptase) regulates the telomerase activity. The increased expression of non-active spliced hTERT results in inhibition of telomerase. However, very little …
GENE EXPRESSION OF INTEGRIN RECEPTORS AND THEIR LIGANDS IN PAPILLARY THYROID CARCINOMA WITH DIFFERENT BRAF V600E MUTATION STATUS
Introduction. Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. As the most frequent genetic alteration BRAF V600E mutation in PTC leads to changes in the activity of intracellular signaling pathways. As a result, expression…