Table of contents
ОБЗОРЫ
MITOCHONDRIAL TRANSPORT MOLECULES AS THE POTENTIAL OBJECTS FOR TARGETED THERAPY
Mitochondria are the active cell organelles whose structures (the membrane in particular) express a large number of signaling molecules, proteins mainly, that play an important regulatory role in cell active functioning. The biological activity of mitochondria…
SIGNALING MOLECULES OF TUMOR TRANSFORMATION IN TUBERCULOSIS
The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the …
APPLICATION OF MESENCHYMAL STEM CELLS AND EXTRACELLULAR VESICLES IN INFECTIOUS TREATMENT
Mesenchymal stem cells (MSCs) are attractive in various fields of regenerative medicine due to their therapeutic potential and complex unique properties. Basic stem cell research and the global COVID-19 pandemic have given impetus to the development of cell th…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
COMPARATIVE STUDY OF THE SOLUBLE FORMS OF IMMUNE CHECKPOINT PROTEINS VISTA, PD-1, PD-L1, AND BONE HOMEOSTASIS REGULATOR RANKL IN BONE TUMOR PATIENTS
Background. Low sensitivity of bone tumors to various schemes of standard chemotherapy stimulated the search of new targets for their medicamentous treatment. Among such targets are the so-called “immune checkpoints” promoting the escape of the tumor from the …
RELATIONSHIPS OF HEMOSTASIS INDEXES AND MICROCIRCULATORY HEMODYNAMICS INDICATORS IN KNEE AND HIP JOINT TRANSPLANTATION
Aim of investigation. The development of a non-invasive express method for assessing the state of the hemostasis system during transplantation of large joints is an urgent task, since it allows you to adjust the appointment of anticoagulant therapy and prevent…
CYCLINE DEPENDENT KINASE 4 DECREASED LEVEL IN THE POPULATION OF Ki-67-NEGATIVE MELANOMA CELLS
Introduction. A transition of proliferating cancer cells to a G0 phase of a cell cycle considered to be implicated in cancer cell drug resistance. The aim of the study. A separation of G0-positive melanoma B16 cells fraction that correspond to resting followed…
POSSIBILITIES OF APPLICATION OF ALLOGENIC TISSUE ENGINEERING PRODUCTS IN THE EXPERIMENTAL URINARY BLADDER RECONSTRUCTION
The article describes the results of an experimental study of tissue-engineering constructions based on lactic acid – poly-L,L-lactide, containing allogeneic cells of various tissue origin. Aim: to show experimentally the possibility of using an allogeneic tis…
OUTCOMES OF TUBERCULOSIS COMBINED WITH HIV INFECTION
Introduction. The epidemiological process in tuberculosis is negatively affected by the HIV epidemic, the identification of vulnerable groups in relation to the unfavorable course of tuberculosis in combination with HIV infection will improve approaches to tre…
CORRECTION OF ALCOHOL-INDUCED DISORDERS OF WORKING MEMORY WITH NOOPEPT
Introduction. Nootropic drugs are used at all stages in treatment of behavioral disorders associated with alcohol consumption, when the correction of the functions of operational (working) memory and attention contributes to a more adequate processing and assi…