Table of contents
ОБЗОРЫ
FUNCTIONAL CHARACTERISTICS OF THE RAGE MOLECULE IN INTERCELLULAR INTERACTIONS IN NORMAL AND LUNG PATHOLOGY
Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unk…
THE ROLE OF FILAGGRIN IN THE FORMATION OF SKIN BARRIER DYSFUNCTION
Dysfunction of the epidermal barrier plays an important role in the development of skin inflammatory processes. Pathological changes in the intracellular composition of keratinocytes are an integral part of the modern understanding of the pathogenesis of atopi…
Key markers of ferroptosis
Introduction. Ferroptosis is a type of programmed cell death associated with excessive accumulation of endogenous iron in the cell, accompanied by the production of reactive oxygen species and, as a result, lipid peroxidation. The literature review examines th…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
The study of beta-glucan immunomodulating effect in the organotypic culture of rat immune tissue
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body. Purpose of the study. The purpose of this study was…
ELASTIC AND HYPERELASTIC PROPERTIES OF THE HUMAN NAIL PLATE
Introduction. As is known, changes in the nail, as an appendage of the skin, can be genetically determined, caused by injuries, diseases, medications or exposure to harmful substances. Installation of partial or complete dentures may be required for any form o…
DACARBAZINE INITIATES SIRT1-INDEPENDENT OVEREXPRESSION OF ANTI-APOPTOTIC BCL2 IN MELANOMA CELLS IN VIVO
Introduction. Cancer cell drug resistance in melanoma is associated with evasion of apoptosis-induced stimuli. Assessing the level of expression of the BCL2 and SIRT1 genes in distant organs and the tumor node makes it possible to assess the resistance of mela…
Interleukins and metalloproteinases in the lungs of mice with BCG-granulomatosis with the injection of the liposomal form of dextrazide
Introduction. An actual decision of the issue of safety and effective drug therapy improvement is the development of transport systems that allow to provide targeted delivery of drugs to target cells, while reducing their toxic effects. The aim of the work was…
PATHOGENETIC ROLE OF CHANGES SERUM LEVEL INTERLEUKIN-4 DURING THERAPY FOR ULCERATIVE COLITIS
Introduction. An important pathogenetic link in systemic inflammation in ulcerative colitis (UC) is dysregulation of the immune response. The aim of the study: to study pathogenetic changes in the serum level of interleukin (IL)-4 during UC therapy. Methods. 6…
DIFFERENT CONCENTRATIONS OF PEROXYNITRITE CAUSE A UNIQUE CELLULAR RESPONSE OF ENDOTHELIOCYTES IN VITRO
Introduction. The study of the effect of peroxynitrite, as a product of nitric oxide (II), on the culture of endothelial cells in vitro can contribute to fundamental ideas about the violation of the adhesive function of the endothelium when changing the synthe…