Table of contents
ПЕРЕДОВАЯ СТАТЬЯ
Legal provision for the use of big data in medicine
The use of big data in medical practice is a promising direction in the development of digital personalised medicine. Legal regulation of the use of big data in medical practice is a relevant issue. Legal regulation of the use of big data is based on the need …
ОБЗОРЫ
The role of oxidative stress in the formation of adaptive processes in the body
Introduction. Oxidative stress (OS) occurs in various pathological processes, and acting as a nonspecific link in their pathogenesis. Less is known about its physiological role. The aim of study. Analysis of the results of world literature data and our own res…
The role of cytokines in neuroimmunoendocrine mechanisms of thyroid pathology
Introduction. Studies consider the immune and neuroendocrine systems as actively interacting with each other and priority participating in the complex maintenance of homeostasis. Immune processes are dependent on the functional activity of the endocrine system…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Prognostic significance of expression of signal molecules to evaluate the metastasis of carcinoma of various locations
Relevance. Ectopic secretion, which occurs in the early stages of tumor development, is not only one of the first signs of a neoplasm, but can also indicate the severity of the oncological process. Purpose of the study: To evaluate the possibility of using the…
Immunohistochemical substantiation of the possibility of use electrochemical method whith using nanotechnological biosensors for assessing alkaline phosphatase activity in tissue colorectal carcinoma
Introduction. Alkaline phosphatase (ALP) is an enzyme from the class of hydrolases, widely present in human tissues and organs. Intestinal ALP is one of the enzyme isoforms that is expressed in the mucous membrane throughout the intestine and is a marker of in…
Features of proliferation and apoptosis of pancreatic cells after administration of N-acetylcysteine in a model of acute post-radiation pancreatitis
Studies of post-radiation lesions of the pancreas after irradiation with charged particles (electrons, protons) are few, however, electron therapy is one of the promising methods in radiobiology and can be used to model post-radiation pancreatitis. The mechani…
Induction of hyperglycemia and accompanying biochemical and genotoxic changes in mice of different strains by tyloxapol
Introduction. Hyperglycemia inducers, the «classic» diabetogens streptozotocin and alloxan have a pronounced effect and are therefore limited suitable for modeling mild hyperglycemia in an experiment. Tyloxapol (Triton WR1339) was chosen as an alternative agen…
Stimulating effect of encoded amino acids combinations on cellular proliferation in organotypic culture of tissue
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation balanced status in the organism tissues is one of the actual task of modern biology and medicine. Purpose of study. Effect of encoded amino acids combination…
The role of the AKT1 gene in the pathogenesis of type 2 diabetes mellitus and its complications
Introduction. Type 2 diabetes (T2D) is a chronic metabolic disorder. The number of diabetic people is increasing. AKT1 is a protein kinase and a participant in the PI3K/AKT/mTOR signaling pathway. The aim of the study was to analyze the association of polymorp…