Table of contents
ОБЗОРЫ
MODIFICATION OF HYALURONIDASE MICROENVIRONMENT: INNOVATORY APPROACHES FOR DEVELOPMENT OF BIOCATALYTIC MEDICAL PREPARATIONS
The computational study of 3D-model hyaluronidase interaction with shortchain glycosaminoglycan ligands had performed demonstrating the diversity and significance of their reaction on enzyme structure. The purpose of this review was evolution of limiting enzym…
SEQUENCING OF SINGLE CELLS: APPLICATION AND PERSPECTIVES
Introduction. Sequencing of single cells makes it possible to characterize the cellular and molecular composition of tissues, the state of DNA, RNA and expressed proteins. The «single-cell» sequencing method is gaining increasing popularity in modern biology a…
Biomarkers of oxidative stress and proteopathies in the diagnosis of neurodegenerative diseases
Introduction. Despite numerous studies in the field of neurodegenerative diseases, the exact mechanisms of these processes have not yet been identified. The purpose of this review is to analyze the methodological approaches necessary to revise the traditional …
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
BIOLOGICAL MODEL OF LUNG CANCER COMBINATION AND TUBERCULOSIS: DEVELOPMENT FOR PRECLINICAL STUDY OF RATIONAL COMBINATIONS OF TARGETED ANTITUMOR AND ANTITUBERCULOSIS THERAPY
Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…
INFLUENCE OF FIBROBLAST GROWTH FACTOR-2 ON THE ACTIVATION OF MOUSE HIPPOCAMPAL MICROGLIA IN A LIPOPOLYSACCHARIDE-INDUCED NEUROINFLAMMATION MODEL IN VITRO
Introduction. Activation of the pro-inflammatory phenotype of microglia may be one of the causes of chronic neuroinflammation and, as a result, can lead to pathological conditions of the brain. The use of neurotrophic factors, such as FGF2, may become one of t…
Individual trombocity reactivity in hematuria associated with nephrolitiasis: the role of purinergic signalisation in the treatment of nesteroid protective preparations
Aim of the study was to establish the significance of TR-receptor, P2X1-receptor and P2Y-receptor synergism for the efficiency of TC aggregation in patients with different sensitivity to non-selective NSAIDs, which will allow us to approach an understanding th…
FEATURES OF THE METABOLISM OF SIALOGLYCOPROTEINS IN THE TISSUES OF THE LIVER, STOMACH AND SMALL INTESTINE OF RATS UNDER IMMOBILIZATION STRESS
Introduction. Immobilization stress leads to the intensification of free-radical reactions leading to the destruction of sialoglycoproteins of the gastroduodenal zone. The aim of the study. To evaluate the features of the metabolism of sialoglycoproteins in th…
Genetic predictors of the risk of developing complications in the immediate postoperative period following combat trauma
Introduction. Paratraumatic eczema (PTE), being a type of microbial eczema, occurs after surgical interventions, chronic wound healing, accompanied by pronounced inflammatory changes with hyperemia, edema, exudation, soreness and itching. Genetic polymorphisms…
COMPUTER PREDICTION OF PHARMACOLOGICAL ACTIVITY OF SOLANUM TUBEROSUM L. ALKALOIDS
The alkaloids solanine and chaconine were discovered in 1821. However, its did not find medical use due to toxicity. At present, modern research methods have revealed anti-cancer activity of the alcaloids. In this regard, the hypothesis of the presence of othe…
EVALUATION OF IMMUNOTROPIC PROPERTIES OF GLYPROLINE COMPOUNDS IN EXPERIMENTAL HYPERTHYROIDISM
Introduction. Thyroid disease is currently the most common among endocrine pathology. Hyperproduction of thyroid hormones is accompanied by stimulation of humoral reactions, contributing to the development of immune-mediated pathology under certain conditions,…