Table of contents
ОБЗОРЫ
Immune microenvironment in hepatocellular carcinoma: current concepts and the role of blockade of immune checkpoints
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The specificity of the immune microenvironment of an organ limits the possibilities of traditional therapeutic and surgical approaches to treatment, therefore one of the mo…
INTERLEUKIN-11 AND CARDIOVASCULAR PATHOLOGY
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. An important task in cardiology is the search and study of new biomarkers. Scientific interest is actively focused on the study of interleukin-11 (IL-11). The purpose of the literature…
Biomarkers of endothelial damage and their role in predicting the development of sepsis and septic shock
Introduction. Sepsis is multiple organ dysfunction in response to the generalization of an infectious process. The likelihood of developing sepsis correlates with the value of biochemical parameters, which can serve as prognostic markers. The endothelium, as t…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Trace elements and the inflammatory process development: predictive possibilities
Introduction. Late diagnosis of inflammatory pathologies leads to increased risks of chronicization of the process, generalization, development of complications, and reduced effectiveness of therapy. Routine methods of clinical laboratory diagnostics often hav…
EFFECTIVENESS AND SAFETY OF CARBOPLATIN-CONTAINING ANTITUMOR THERAPY REGIMENS IN A MODEL OF COEXISTANCE OF LUNG CARCINOMA AND TUBERCULOSIS
Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …
Mitochondrial proteins as biomarkers of occupational disease risk of pilots and astronauts
Introduction. Mitochondrial dysfunction is an important pathogenic mechanism of neurodegeneration, characterized by a progressive structural and functional loss of neurons, leading to heterogeneous clinical and pathological manifestations with subsequent impai…
Biomechanical properties of nasal tissues
Introduction. Plastic rhinosurgery and augmentation rhinoplasty are very relevant today. Especially in relation to patients with congenital saddle deformity of the nasal dorsum, as well as patients with iatrogenic disorders of the nose shape, which dramaticall…
EVALUATION OF THE EFFECT OF NEUROPEPTIDES OF THE MELANOCORTIN FAMILY ON STRESS-ASSOCIATED CHANGES IN THE LEVEL OF CORTICOTROPIN-RELEASING HORMONE AND CORTICOSTERONE
Introduction. To date, the problem of studying the neuropeptide system of regulation of adaptive processes is relevant, since the stress reaction is a trigger for the occurrence of various diseases, in particular depression. Corticoliberin is considered as the…