Table of contents
ОБЗОРЫ
Imbalance of immunoregulatory molecular cellular mechanisms as a cause of recurrent miscarriage
Introduction. Recurrent pregnancy loss (RPL) is an early spontaneous termination of pregnancy before 20 weeks, which is defined as two or more miscarriages. Most of the known causes associated with the pathophysiology of RPL include endocrine disorders, antiph…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Indices of glycemic variability as the basis for building a prognostic model for the development of diabetic complications
The use of mathematical indices of glycemic variability (IGV) opens up new possibilities in predicting diabetic complications, which allows more accurate correction of therapy and prevention of the development of acute and chronic conditions. Aim. To analyze t…
Effect of the dipeptide retro-analog of cholecystokinin tetrapeptide (GB-115) on the behavior of rhesus monkeys in isolation
Introduction. The developed domestic dipeptide retro-analog of cholecystokinin (CCK) tetrapeptide (N-(6-phenylhexanoyl)-glycyltryptophan amide, compound GB-115) with antagonistic properties towards CCK1 receptors has anxiolytic activity, previously shown in pr…
Comparison of the sensitivity of restriction analysis and PCR with high-resolution melting curve analysis for the detection of the R882H mutation in the DNMT3A gene
Introduction. DNMT3A is one of the most frequently mutated genes in acute myeloid leukemia (AML), and the R882H (G>A) substitution is one of the most common mutations in this gene. Restriction analysis and high resolution melting (HRM) analysis are the most co…
Poisson’s ratio of fluorapatite crystals
Introduction. It is known that in the pathogenesis of caries and non-carious lesions of teeth, an important role is played by enamel resistance, which is determined by numerous factors, among which the structure and physical and mechanical properties of tooth …
Molecular biological analysis of clinical and pathogenetic features of the formation of postoperative complications in combat trauma
Introduction. Pathological scars (PS) occur after traumatic injuries, surgical interventions, burns, etc. lead to functional disorders, cosmetic defects, and also significantly affect the quality of life. The results of studies to determine the genetic determi…
Diagnostic significance of antioxidant protection indicators for assessing the course of post-Covid syndrome
Introduction. An increasing number of reports of long-term negative consequences of COVID-19, characterized by chronic inflammation, tissue hypoxia, oxidative stress, metabolic changes at the level of all body systems, determines the search for criteria for as…
Experimental replacement of various bladder volumes with allogeneic tissue-engineered constructions
The results of experimental replacement of the bladder wall up to subtotal using multicomponent tissue-engineered structures are presented. Purpose. Development and experimental use of a tissue-engineered structure for replacing various volumes of the bladder …
Identification of mast cells in the brain of mice with lipopolysaccharide-induced neuroinflammation
The purpose of the present study was to identify mast cells in brain sections of mice with neuroinflammation induced by intraperitoneal injections of LPS. Material and methods. The subjects of the study were nonlinear mice that received intraperitoneal injecti…