Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Expression of immune checkpoints by tumor microenvironment Т-lymphocytes in colon cancer
The study of immune checkpoint expression by tumor microenvironment T-lymphocytes is necessary for understanding the pathophysiological mechanisms of tumor immunosuppression, as well as for the development of new methods of targeted therapy for colorectal canc…
Stimulating effect of peptides in organotypic tissue culture of rat genitourinary system
Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the stimulating effect on the organs of genitourinary system. Purpose of study. Study of stimulating effect on cellular proliferation of…
Levels of GFAP, Iba1, TNF-α, and caspase-3 in the cingulate cerebral cortex of mice after intraperitoneal lipopolysaccharide
Introduction. Bacterial lipopolysaccharide (LPS) affects the structure and function of nervous tissue cells. The aim of the study: to explore the impact of intraperitoneal LPS given to mice on levels of such markers as glial fibrillar acidic protein (GFAP), ad…
Quantitative indicators of TREC and KREC as predictors of the severity of acute respiratory infections in children
Аmphocyte production and indirectly reflect the state of the adaptive immune system. Their concentration in dried blood spots can be determined by quantitative polymerase chain reaction (qPCR). Currently, these markers are used for neonatal screening of primar…
A personalized approach to the treatment and prevention of diabetic foot: molecular mechanisms and the role of taxifolin
Aim. To substantiate the pathogenetic rationale for including aqueous solution of dihydroquercetin (taxifolin) in the comprehensive treatment of diabetic foot and to present the results of a case series on the application of this form in patients with trophic …
ОБЗОРЫ
Blood exosomes of patients with malignant neoplasms of bones and articular cartilage: connection with tumor progression and practical value in clinical medicine
Relevance. Primary malignant neoplasms of bones and articular cartilage account for about 0.2% of all cancer cases and are characterized by an aggressive course, high tendency to metastasize, and resistance to therapy, which leads to unsatisfactory survival ra…
Molecular markers of the development of posttraumatic stress disorder
Introduction. Posttraumatic stress disorder (PTSD) is presented as a systemic multilevel metabolic-immuno-psycho-neurological disorder with genetic predisposition and epigenetic influences, which radically changes the approach to its understanding and treatmen…
Matrix Metalloproteinase Polymorphisms as Predictors of Osteoarthritis
This review was conducted to systematize data on the association of matrix proteinase gene polymorphisms (MMP, ADAMTS, ADAM) with the risk of developing osteoarthritis. Material and methods. A systematic literature search of PubMed and Web of Science databases…
Effects of short peptides on the molecular mechanisms of aging in laboratory primates
Introduction. Short peptides are considered a promising class of geroprotective agents capable of modifying key molecular mechanisms of aging, from epigenetic regulation of gene expression to maintenance of neuroendocrine and antioxidant homeostasis. Laborator…
Synergism of ascorbic acid and RNA interferon inducers in antiviral immunity activation: molecular mechanisms and therapeutic perspectives
Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…
A study of the transformation of digital twins into personalized medicine
Introduction. To date, digital twins are the most promising area for the development of modern healthcare. With their help, it is possible to radically change approaches to the diagnosis, treatment and prevention of diseases. In medicine, the concept of digita…
Selenium: biochemical role and the importance of balance in the human body
The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…
Immunopathology of trauma: relationship between physical damage to the musculoskeletal system and the development of rheumatic diseases
Introduction. A physical injury triggers a cascade of pathological processes, including the activation of the immune system and the development of local inflammation. Hereditary predisposition, pronounced structural changes, biomechanical disorders, and comorb…