Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
Synthesis and study of a triple chelated iron complex with folic acid and L-valine.
Objective. Mixed organometallic complexes containing amino acids and water-soluble vitamins as ligands are promising research subjects in organic and physical chemistry. The practical applications of these compounds may include medicine, where they are conside…
Telemedicine screening and three-year follow-up of stress-associated autonomic dysfunction in students during university adaptation: clinical and digital risk stratification and personalized prevention
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…
Asprosin and meteorin-like peptide: new markers and potential targets in childhood obesity
Currently, there is no existing data on the role of asprosin and meteorin-like protein (Metrnl) in the pathogenesis of obesity in children. Purpose of the study. To assess the relationship between the levels of adipomio-cins asprosin and Metrnl with body compo…
Molecular patterns of RNA pathogens and immune response to exogenous RNA: recognition mechanisms and therapeutic potential
Introduction. Innate immunity represents the first line of defense against pathogens, based on recognition of conserved molecular patterns (PAMPs) through specialized pattern recognition receptors (PRRs). RNA-containing viral patterns are of particular importa…
The role of markers of chronic inflammation in the progression of sarcopenic obesity in type 2 diabetes mellitus
The pathogenetic process of sarcopenic obesity (SO) development is multifactorial, the key of them is considered – non-specific systemic inflammation. Objective. to assess the influence of the intensity of the course of chronic inflammation in patients with ty…
Integrative role of biomarkers and trace element profiles in risk assessment and stratification of metabolic syndrome in gastroenterology patients
Metabolic syndrome (MS) is a cluster of conditions including abdominal obesity, hypertension, dyslipidemia, and hyperglycemia that are very common in developed countries. The prevalence of MS increases annually. In recent years, a significant increase in the p…
ОБЗОРЫ
Bacterial factors in reduced male fertility (literature review)
Introduction. Male infertility is a complex medical problem affecting a significant part of the male population. According to the WHO, about 15% of couples worldwide face infertility problems, and in 40-50% of cases the cause is attributed to the male factor. …
Molecular medicine: modern tactics and strategy of diagnostics and treatment of diseases
The aim of the review is to analyze the main trends in the development of molecular medicine and to establish the dependence of the development of modern informative diagnostic tests and treatment methods on new knowledge about the biochemical processes develo…
Differences in the genetic landscape of primary gastric adenocarcinoma and its regional lymph node metastases
Introduction. Lymphogenous metastasis is a key stage in the progression of gastric cancer. The practice of personalized treatment has historically been based on histological and molecular analysis of the primary tumor, while the molecular-genetic landscape of …
Current advances in the study of molecular pathogenesis of breast cancer
Introduction. Breast cancer (BC) is a heterogeneous disease that represents a major global health problem. It is the most frequently diagnosed cancer in the world, with the incidence of breast cancer increasing year by year in most countries. The existence of …