Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
THE INVOLVEMENT OF GLUTAMATE AMPA RECEPTORS IN THE REGULATION OF T-CELL ADHESION IN MULTIPLE SCLEROSIS
Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…
Toxic metabolites of aromatic amino acids in autism spectrum disorders
Objective. To investigate the role of toxic metabolites of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) in autism spectrum disorders (ASD) pathogenesis and their relationship with intestinal dysbiosis. Material and methods. The study included…
Features of the endoscopic and morphological patterns of the esophageal mucosa in eosinophilic esophagitis in children of different age groups
Introduction. The incidence of eosinophilic esophagitis is 5.31 cases per 100,000 person-years. It is a multifactorial disease with a clear genetic predisposition, specifically involving the expression of the thymic stromal lymphopoietin and IL-33 genes. Eosin…
Proteomic reprogramming of senescent mesenchymal stromal cells of adipose tissue: a role in the modulation of macrophage phenotype and the formation of inflammageing in obesity
The study is devoted to the identification of changes in the proteomic profile of senescent mesenchymal stromal cells of adipose tissue, which determine the modulation of the macrophage phenotype and are involved in the pathogenetic cascade of the formation of…
FEATURES OF SHIFTS IN THE INDICATORS OF IMMUNE-ANTIOXIDANT STATUS IN RESIDENTS OF THE KRASNODAR TERRITORY SUFFERING FROM POLLINOSIS
Background. Pollinosis is a progressive allergic disease mediated by an IgE-dependent reaction associated with the activation of inflammatory processes, oxidative stress and lipid peroxidation, which affects, first of all, the membrane structures of various ce…
APPLICATION OF RING-POLYHEDRAL MODELS OF AMINO ACIDS FOR PROTEIN STRUCTURE MODELING
Introduction. The article is devoted to the theoretical prediction of the spatial structure of proteins of protein three-dimensional structures, with a focus on the specifics of modeling chemical compounds containing a significant number of amino acid residues…
Comparative analysis of Hsp27 and Hsp90 expression in high- and low-grade ovarian carcinoma cells
Introduction. Ovarian cancer is characterized by high mortality. Despite available diagnostic and therapeutic methods, patient survival remains unsatisfactory, especially for high-grade tumors, necessitating the exploration of new molecular targets. Heat shock…
ОБЗОР
Branched chain amino acid transaminases: structure, molecular and genetic aspects, functional and pathogenetic role
This review systematizes current data on branched-chain aminotransferases (BCATs). Their molecular structure, classification as fold type IV pyridoxal phosphate (PLP)-dependent enzymes, and catalytic features are discussed in detail. The differences between th…
YEAST RNA AS A SOURCE OF IMMUNOMODULATORY NUCLEOTIDES: FROM BIOCHEMISTRY TO CLINICAL APPLICATION
Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…
Optimization of ctDNA and cfDNA detection: modern bioinformatic approaches to improve the accuracy of molecular diagnostics of tumors
Relevance. Modern approaches to detecting circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) demonstrate high potential for improving the accuracy of molecular diagnostics of tumors and require a comprehensive analysis of all stages, from the biology of f…
Digital twin of early immunometabolic response after tick bite. LC-MS/MS profiling of lipid mediators and the kynurenine pathway in a QSP model of systemic inflammation
Tick bite is traditionally viewed in clinical practice primarily as an event associated with the risk of pathogen transmission. Although this interpretation is epidemiologically justified, it does not capture the molecular layer that develops within the first …
THE POSSIBILITIES OF TELEMEDICINE TECHNOLOGIES TO PROVIDE A PERSONALIZED APPROACH IN CARDIOLOGY THROUGH THE USE OF WEARABLE DEVICES
Cardiovascular diseases remain one of the main causes of hospitalization, disability, and mortality. The usual monitoring model and rare face-to-face visits often do not keep up with the actual clinical dynamics. This partly explains the growing interest in we…