Abstract
The dependence of biochemical markers of bone resorption (C-terminal telopeptide of type I collagen – b-CTx, deoxypyridinoline –
DPID, tartrate-resistant acid phosphatase (TRAP) 5b) and osteosynthesis (bone alkaline phosphatase – BALP) on clinical manifestations
of bone metastases in 239 patients with breast cancer (BC) has been established with the use of ELISA method. In patients with bone
metastases (n=72) DPID excretion in the urine, and the seru concentration of CTx and activity of TRAP and BALP level were found to
be significantly higher if compared with BC patients without bone lesions (n=167), and healthy females (n=47). However, their significant
increase (p <0,05–0,0001) depended on the extent of skeletal involvment (b-CTx, BALP), the presence of a pathological fracture (b-CTx,
TRAP, BALP) and severity of pain syndrome (b-CTX, DPID, TRAP, BALP) . Intensification of the processes of bone remodeling was
associated with a significant decrease in overall survival rate of BC patients. Highly significant differences in overall survival rate, calculated
with taking into account the threshold levels of b-CTX (0,74 ng/ml) and BALP(43.7 U/l) were obtained in the total group of BC patients
and when analyzing the group of patients with initial bone metastases, and without lesions of the skeleton. Being the most significant criteria
b-CTx and BALP have independent value in monitoring and prediction of skeletal metastases in BC patients.
Keywords
Authors and affiliations
N.V. Lyubimova (1), G.V. Kozarskaya (2), T.V. Ageeva (1), S.M. Portnoy (1), A.V. Maslyaev (1), N.E.Kushlinsky (1)
1 -Federal State Budgetary Institution «N.N. Blokhin Russian Cancer Re-search Center of the Russian Academy of Medical Sciences,
2 -State Budgetary Establishment of Healthcare «Oncological dispensary №5 of the Moscow Healthcare Department»