Abstract
The work is devoted to the study of the expression of the signaling molecules involved in apoptosis, proliferation, extracellular matrix
remodeling and the formation of immune status of the pineal and thymus glands. In the pineal and thymus glands in people over 60 years
old the cross-correlation between the expression of the signaling molecules CD5 and MMP9 has been found. In both organs age associated
decline in expression of MMP2 CD5 was verified. The role of matrix metalloproteinases MMP2 and MMP9 in the involution of the thymus
and the pineal gland, and the dynamics of the immune status of the both tissues during aging has been shown.
Authors and affiliations
N.S. Lin’kova (1), V.O. Polyakova (2), T.V. Kvetnaia (1), A.S. Katanugina (1), A.V. Kostylev (1), R.I. Abdulragimov (1), N.N. Sevostyanova (1)
1 -Saint-Petersburg Institute of Bioregulation and Gerontology of the North-West Branch of the Russian Academy of Medical Sciences
2 -Federal State Budgetary Institution «The Research Institute of Obstetrics and Gynecology named after D.O. Ott» of the North-West Branch of the Russian Academy of Medical Sciences