Abstract
Spiral computed tomography (CT) with contrast enhancement allows both to study changes of densitometric parameters in different
phases of research and to get information about the features of vascularization in the focal formation of liver, which underlies the differential
diagnosis of tumors.
There was carried out as well comparative analysis of the characteristics of vascularization of focal nodular hyperplasia (FNH) of
different size as computed tomography and morphological study of 15 patients (4 males and 11 females aged 14–68 years). All patients were
undergone spiral CT with bolus contrast enhancement (on four phases of the study) preoperatively. With morphometric methods there were
determined the number and total area of the lumen of branches of arteries and sinusoids on histological (stained with hematoxylin and eosin)
and immunohistochemical (reaction with CD34) preparations of resected tissue from FNH
With the densitometric analysis of tomograms there were established changes of the average CT density of FNH tissue depending on the
phase of the research and size of FNH. For almost all the structures the increase CT density of FNH tissue was typical only in the arterial
phase, most pronounced in small tumors. On histological preparations they were also determined the highest values of the number and total
area of the sinusoids, and the highest values of the cross section of branches of arteries and total area of the blood vessels, which characterize
the degree of vascularization of the tissue. The lowest increase of CT density, the number of sinusoids and the degree of vascularization were
registered in large tumors.
Authors and affiliations
U.N. Tumanova (1,2), E.A. Dubova (2), G.G. Karmazanovsky (1), A.I. Shchegolev (2)
1 -Vishnevsky Institute of Surgery, Moscow,
2 -Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Moscow