Table of contents
Articles
INFLUENCE OF D-1208I GENE POLYMORPHISM ON TISSUE FACTOR ACTIVITY
reduced levels of monocytic TF expression in comparison with homozygous ones (160,1±53,0% and 198,6±72,9% M±SD, accordingly). If compared with homozygous allelic variants D-1208I heterozygous genotype is associated with less macrophagic TF expression in lungs …
HEAT TREATMENT ENHANCES REGENERATION CAPACITY OF SERTOLI CELLS
Sertoli cells are the primary cells that support developing spermatogenic cells in the seminiferous tubules. Heat treatment induces a reversible change in the Sertoli cells (SC) from the mature differentiated state to an immature-like dedifferentiated state. W…
THE ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISMS AND THE RISK OF MISCARRIAGE
In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to p…
THE ROLE OF AROMATASE EXPRESSION IN THE PATHOGENESIS OF GENITAL ENDOMETRIOSIS
The role of aromatase P450 in the pathogenesis of external genital endometriosis (IEG) has been investigated. 45 women with endometriosis have been included in the study, the group of comparison was consisted of 9 healthy women. The examination included a lapa…
PROTEASOME AND CALPAIN ACTIVITIES IN ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL CANCER
In present study, we investigated the proteasome and calpain activities in patients with endometrial hyperplasia (EH) and endometrial cancer (EC), as well as proteasome subunit composition in EC tissue. EC development was shown to be associated with increased …
3,3’-DIINDOLYLMETHANE IS A SELECTIVE INHIBITOR OF CANCER STEM CELLS ACTIVITY
There is a growing body of evidence confirming the validity of the concept of cancer stem cells (CSCs). It is becoming increasingly obvious that CSCs, possessing higher tumorigenicity, metastasis-initiating activity and chemoresistance, are a source of tumor g…
TRANSLATIONAL MEDICINE – A NEW STAGE OF MOLECULAR MEDICINE DEVELOPMENT
In recent years, scientists from different countries are actively discussing the concept of translational medicine and consider it as important area of molecular medicine development. Translational medicine promotes the transfer of discoveries made in basic bi…
HEALTH RISK ASSESSMENT FROM IMPACT OF NANO-, NANOBIOMATERIALS:METHODS OF EVALUATION AND PRACTICAL APPLICATION
An approach to the development of methodology for health risk assessment (HRA) for the effects of new environmental factors: nanoparticles and nanobiomaterials (NP/NBM) – products of modern nano-, nanobiotechnology has been proposed. The experience from develo…
SIGNALING MOLECULES IN BUCCAL EPITHELIUM: OPTIMIZATION OF DIAGNOSIS OF SOCIALLY SIGNIFICANT DISEASES
Buccal epithelium (BE) is an easily accessible target for molecular diagnosis of various diseases, and non-invasive way to get it is possible. This review summarizes the results of studies indicating a change in the expression of various signaling molecules an…
NUCLEOPHOSMIN AND NUCLEOLIN: ENCODING GENES AND EXPRESSION IN VARIOUS HUMAN AND ANIMAL TISSUES
Argirophilic proteins of nucleolar organizer regions (Ag-NOR) pose a wide group of nucleolar proteins specifically stained by AgNO3. Expression level of Ag-NOR proteins in proliferating cells, including tumor ones, is commonly high. Nucleophosmin/B23 and nucle…