Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
EXPRESSION OF AORTA ENDOTHELIUM SIGNALING MOLECULES IN AGEING AND ATHEROSCLEROSIS
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …
MOLECULAR MECHANISMS OF DERMAL GEROPROTECTIVE ACTION OF DRUGS BASED BIOMIMETIC PEPTIDE
Introduction. Biomimetic peptides – are synthetic compounds which are identical to amino acid sequence that are synthesized by organizm, which can interact with growth factor receptors and provide antiaging clinical effect. The aim of the study. Investigation …
THE STUDY OF THE EFFECT OF INTERACTION BETWEEN GENES, ASSOCIATED WITH PHENOMENON OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS COMPLEX
Introduction. The phenomenon of drug resistance of Mycobacterium tuberculosis complex is extremely complicated. The determination of the genetic changes is not always able to explain reasons of this effect clearly. The aim of the study. Molecular genetic analy…
FREQUENCY AND SPECTRUM OF KRAS GENE MUTATIONS IN ADVANCED COLORECTAL CANCER. CLINICAL AND MORPHOLOGICAL CHARACTERISTICS
Introduction. KRAS mutations play a critical role in human tumorigenesis and are the most prevalent in colorectal cancer. Because KRAS is the most frequently mutated factor downstream of the EGFR signaling pathway, it was considered to be a candidate molecular…
NEURON-SPECIFIC PROTEINS AS MARKERS OF SELECTIVE EVALUATION OF ALTERATION PROCESS OF NERVOUS TISSUE IN ACUTE AND EARLY PERIODS OF TRAUMATIC SPINAL CORD DISEASE
Introduction. Owing to the intensive development of neurosciences immunoassay methods have received a widespread use. These methods allow studying the functioning features of the nervous system in trauma at the molecular level . The purpose of the study. The p…
CHARACTERISTICS OF STEROIDOGENESIS IN THE TUMOR AND SURROUNDING TISSUES IN EXPERIMENTAL MELANOMA B16
Introduction. Hormonal aspect in the pathogenesis of melanoma development is still poorly studied. Tumor transplantation to experimental animals allows to study the effect of malignant process on different systems and organs, detect the saturation of tumor and…
ROLE OF MOLECULES OF ANGIOGENESIS IN INTERSTITIAL LUNG DISEASES
Introduction. In interstitial lung diseases (ILD), characterized by inflammatory and fibrous processes, the intensification of angiogenesis also occurs. The aim of our research. Was the study of characteristics of expression angiogenic molecules (VEGF, ET1) in…
PREVALENCE OF CYP2C19 GENETIC POLYMORPHISMS IN RUSSIAN PATIENTS WITH PEPTIC ULCERS TREATED WITH PROTON PUMP INHIBITORS
Introduction. Cytochrome P-450 2C19 is the main isoenzyme responsible for the metabolism of proton pump inhibitors, the main group of drugs for treating stomach and duodenal ulcer. There are genetic differences that affect the activity of this enzyme: there ar…
GENE EXPRESSION OF ESTRADIOL AND PROGESTERONE RECEPTOR IN THE ENDOMETRIOSIS TISSUE OF OVARIAN
Introduction. Endometriosisis a commonovarianhormone-dependent diseasesin womenof reproductive age. Lack ofeffectiveness of treatmentof this diseasemay be associatedwith gapsof knowledgeabout the molecular mechanismsof its originand development. The aim of the…
PRENATAL HYPERHOMOCYSTEINEMIA AND OXIDATIVE STRESS PROFILE IN THE RAT OFFSPRING
Introduction. Oxidative stress is developed as a result of imbalance between the generation of reactive oxygen species and activity of the antioxidant defence system. This in turn results in profound changes in metabolism of lipids, proteins and nucleic acids,…
INFLAMMATORY MARKERS OF CORONARY ATHEROSCLEROSIS
Introduction. Currently in the world there are conducted numerous studies on the search for biomarkers associated with increased risk of coronary heart disease (CHD). The aim of the study. The study of the levels of such inflammatory biomarkers as the tumor ne…
ОБЗОРЫ
THE PHARMACOGENETIC MECHANISMS OF DEVELOPMENT OF METABOLIC DISORDERS ASSOCIATED WITH THE SECOND-GENERATION ANTIPSYCHOTICS
Antipsychotics are the main medication for schizophrenia treatment. Recently the wideused group of them became second-generation antipsychotics (SGA). Due to that, problem of metabolic disturbances as side effect of SGA is more actually. The development of pha…
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