Table of contents
ОБЗОРЫ
MICRORNAS AS BIOLOGICAL MARKERS OF OVARIAN CANCER
MicroRNAs (miRNAs) – small non-coding RNAs targeting multiple mRNAs – are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. MiRNAs expression is altered in various human tumors including ovarian cancer. Ana…
MESENCHYMAL STEM CELLSAND PEPTIDES: ROLE AND IMPORTANCE INMOLECULARMECHANISMS OFTARGETED THERAPY
Review is devoted to systems for drug delivery of biologically active substances in the tissues and organs of the target cells, which is relevant to medicine. There are described properties of mesenchymal stromal cells (MSCs), which many authors propose to use…
THE ROLE OF INDIVIDUAL GENETIC CHARACTERISTICS OF PATIENTS IN THE EFFICACY OF ANTICOAGULANT THERAPY
The review highlights the problem of the influence of the genetic characteristics of patients in the dosage of anticoagulant drugs, the main adverse reaction of taking of which is the internal bleeding. Therapy with anticoagulant drugs is characterized by a wi…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
SUBPOPULATIONS OF MOBILIZED PERIPHERAL HEMATOPOIETIC STEM CELLS IN CANCER PATIENTS. ASSOCIATION WITH NOSOLOGICAL FORM OF THE DISEASE
Introduction. Currently there was described a number of subpopulations of haematopoietic stem cells and progenitor cells, important for completeness of the recovery of hematopoiesis and antigens involved in the process of homing, adhesion and mobilization of h…
THE STUDY OF INTERFERON GENE EXPRESSION IN THE HUMAN FIBROBLAST CULTURE IN RESPONSE TO IMMUNOMODULATORS AND VIRAL INFECTION
Introduction. Diploid human fibroblasts lines (DHFL) are widely used in diagnostic virology and experimental studies. One of the directions of use DHFL in virology and immunology is to create on their basis of a test system for determining the activity of inte…
QUANTIFICATION OF THE NUMBER OF MITOCHONDRIAL DNA COPIES IN HUMAN OOCYTES WITH DIFFERENT MORPHOLOGICAL ABNORMALITIES
Introduction. In IVF-cycles ≈70% of human oocytes have different morphological abnormalities (dysmorphisms). Embryos from dysmorhic oocytes may have delay in development due to mitochondrial dysfunction and disorders of energy accumulation in the cell. The aim…
THE USE OF HUMAN AMNION IN SKIN BIOENGINEERING
Introduction. Amniotic tissue sheath is unique in its wound-healing properties, including anti-fibrotic, immunosuppressive and antibacterial features, as well as in its ability to stimulate cell proliferation and migration. These properties are further complem…
KISSPEPTIN AND KISSPEPTIN RECEPTOR’S EXPRESSION IN EXTERNAL GENITAL ENDOMETRIOSIS
Introduction. Kisspeptin, was originally identified as a protein suppressing metastasis, since it has the ability to inhibit the migration of melanoma cells. It was established that KISS1 / KISS1R has a significant impact on the process of puberty and regulate…
G276T ADIPONECTIN GENE POLYMORPHISM IN DEVELOPMENT OF OBESITY AND OBESITY-RELATED DISEASES IN KYRGYZ POPULATION
The aim of this work was to study the relationship between adiponectin gene polymorphisms G276T with obesity and obesity-related diseases in the Kyrgyz population. Material and methods. We genotyped 288 Kyrgyz subjects (143 women and 145 men; age range: 30–75 …