Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
THE KED PEPTIDE REGULATES THE SYNTHESIS OF SIGNAL MOLECULES – MARKERS OF ADHESION AND REGULATORS OF TROMBOGENESIS IN INTACT AND DAMAGED VASCULAR ENDOTHELIUM
Introduction. The investigation of molecular and cellular mechanisms of atherosclerosis and the development of restenosis and the possibility of the regulation of these processes by short peptides opens new perspectives for the delivery of vasoprotective prepa…
PROGESTER ONERECEPTION IN THE PERIPHERAL BLOOD MONONUCLEAR CELLS AND THE SUCCESS OF ASSISTED REPRODUCTIVE TECHNOLOGY
Introduction. Low rate of the pregnancy frequency in the IVF programs is one of the challenges in gynaecology nowadays. One of the approaches to enhance the efficacy of the assisted reproductive technology is to estimate the success of the forthcoming procedur…
PROTEOMIC PROFILING OF ESCHERICHIA COLI, ISOLATED FROM CROHN’S DISEASE PATIENTS
Introduction. A possible pathogenesis for Crohn’s disease (CD) involves the provocation of uncontrollable immune response by intestinal microbiota. Escherichia coli is regarded as a candidate for possible pathogen, since its content is increased in intestine o…
ABERRANT TRANSCRIPTIONAL ACTIVITY OF APOPTOSIS-REGULATING GENES IN MALIGNANT NEOPLASM OF CORPUS UTERI
Introduction. The most common invasive malignant tumor of uterine is endometrial cancer. In process of tissues malignancy the critical role belongs to changes in signaling pathways which regulate apoptosis. The aim of study was to analyze changes in the expres…
ТНЕ АСTIVITIES OF PROTEASOMES AND CALPAINS IN THE STOMACH CANCER AND MUCOSA IN FOCAL ATROPHIC GASTRITIS
Introduction. Aproblem of finding of new markers of the development and progression of gastric cancer is actual. In this context, investigations on the role of proteolytic system sin this pathologyare gaining in importance. The aim of the study. The study of t…
EXPRESSION OF SIGNAL MOLECULES IN HUMAN ENDOMETRIUM: OPTIMIZATION OF THE IMPLANTATION SUSCEPTIBILITY UNDER THE ACTION OF ALLOGENEIC PLACENTA HYDROLYSATE
Introduction. The article is devoted to the actual medical and social problem of modern reproductive medicine – new approaches to improve and regenerate the implantation susceptibility of the endometrium in infertility. Currently, in addition to traditional ho…
CARDIOPROTECTIVE EFFECT OF TRIMETAZIDINE IN RATS WITH ESTABLISHED ALCOHOLIC CARDIOMYOPATHY IN THE ABSTINENCE PERIOD
Aim of the study. To study trimetazidine cardioprotective effects on the translation model of alcoholic cardiomyopathy Materials and methods. Alcoholic cardiomyopathy was reproduced in white mongrel male rats used as the sole source of liquid 10% ethanol solut…
THE ANALYSIS OF RASSF1A AND SEMA3B TUMOR SUPRESSOR GENES CPG-ISLANDS METHYLATION STATUS IN UVEAL MELANOMA PATIENTS
Introduction. Uveal melanoma (UM) is a tumor of neuroectodermal origin developing from melanocytes of the uveal tract. The very common pathological characteristic of UM is its metastatic activity in liver, leading to the poor efficiency of the treatment. That`…
ОБЗОРЫ
MONORESISTANCE GENES AS MARKERS IN PERSONALIZED THERAPY FOR LUNG CANCER
Surgery results of the treatment of the stage II–III lung cancer remains to be unsatisfactory, and used the chemotherapy fails to improve the survival. The main obstacle is the use of standard clinical parameters for the treatment strategy and not enough effec…
LEPTIN AND ITS ROLE IN THE DEVELOPMENT OF THE FETUS AND NEWBORN INFANT
The review presents results of clinical and experimental investigations, revealed leptin’s role in the mechanisms of morphological and physiological development of the fetus and newborn. This review summarizes many of the published reports about the leptin’s r…
GENE THERAPY OF PARKINSON`S DISEASE
Modern methods of treatment of Parkinson's disease (PD) remain to be unsuccessful in cessation of the progression of neurodegenerative processes in the brain. The role of certain genes is proven by the etiology of PD, 10–15% of cases represent a monogenic dise…