Table of contents
ОБЗОРЫ
SALIVA AS A BIOLOGICAL OBJECT FOR NON-INVASIVE MOLECULAR DIAGNOSIS OF CARDIOVASCULAR DISEASES
Cardiovascular diseases (CVD) are considered to be one of the leading causes of lethality in patients of older age groups. In the last decade, the issue of finding a material for effective non-invasive diagnosis of CVD has become urgent. The review considers t…
PRIMARY CULTURE OF THYROCYTES, THYROID FOLLICLES AND MICROORGANS OF THE THYROID GLAND AS THE FIRST STAGE OF THE CREATION OF TISSUE ENGINEERING CONSTRUCTS
One of the ways to restore the lost functions of the thyroid gland is the creation of its tissue engineering constructs. The creation of adequate tissue engineering constructs requires either cultures of functionally active thyrocytes capable of forming thyroi…
NON-CODING RNAS: PHYSIOLOGICAL FUNCTIONS AND ROLE IN PATHOGENESIS OF VASCULAR DISEASES
Epigenetics studies inherited mechanisms capable of modulating gene expression without altering the DNA nucleotide sequence. Until very recently, epigenetics included inherited mechanisms, such as DNA methylation and histone modification. As of today, a large …
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
THE INFLUENCE OF SURGICAL CASTRATION ON THE SYSTEMIC INFLAMMATORY RESPONSE INDUCED BY THE ADMINISTRATION OF LIPOPOLYSACCHARIDE TO ADULT WISTAR RATS
Introduction. The incidence of infectious and inflammatory diseases, including sepsis, increases with the age, which is explained by the age-related decrease in the content of sex steroids. However, the features of the course of systemic inflammatory responses…
THE NEW MOLECULAR GENETIC MARKERS OF THE SUDDEN CARDIAC DEATH IDENTIFIED BY NEXT-GENERATION SEQUENCING
The aim of the study is an investigation of the association between mutations A1744S of MYH7, 9928_9929insE of TTN, T171M of CACNA1C, A189T of JPH2, S434Y of VCL, H4552R of RYR2, Y1495X of SCN5A and the sudden cardiac death (SCD). Investigating mutations were …
THE EXPRESSIVE METHOD OF DNA ISOLATION FROM FROZEN BLOOD
Introduction. Mass genotyping, aimed both at identifying of genetic characteristics of populations and the creation of genomic libraries, scientific research, was implemented on large samples, required the accumulation and/or conservation of samples of the bio…
POLYMORPHISM OF VEGF-A GENES AND THE RISK OF THE DEVELOPMENT OF THE EXUDATIVE AGE-RELATED MACULAR DEGENERATION
Introduction. Age-related macular degeneration (AMD), in particular, its exudative form, has for many years held a leading position in the causes of the loss of visual acuity and leads to blindness in 90% of elderly cases. The loss of central vision is based o…
MATRIX METALLOPROTEINESES AND THEIR TISSUE INHIBITORS IN PRIMARY BONE TUMOR PATIENTS: CLINICAL AND PATHOLOGIC CORRELATIONS
Introduction. The search of molecular markers for early diagnostics, prognosis, and identification of new objects for molecular-targeted therapy of primary bone tumors remains one of the most important tasks despite the significant achievements in the treatmen…
QUANTITATIVE DISTRIBUTION OF APOLIPOPROTEIN-E AMONG BLOOD PLASMA LIPOPROTEINS IN HEALTHY MEN
Introduction. Apolipoprotein-E (apoE), being one of the metabolically active apoproteins plays the important role in lipid metabolism. The aim of the study was to investigate the quantitative distribution of apoE between different lipoprotein classes in health…
THE ROLE OF STEROID ER, AR RECEPTORS, BRN-3Α AND TRIM16 NUCLEAR TRANSCRIPTION FACTORS IN THE DEVELOPMENT OF KIDNEY CANCER
Introduction. The study of molecular mechanisms of the development of kidney cancer is one of the actual problems in oncology. There is conflicting information about the importance of steroid hormone receptors in the kidney cancer. The aim of the study was to …
SKIN FIBROBLASTS AS AN OBJECT FOR LIFE-TIME MOLECULAR DIAGNOSTIC OF THE ALZHEIMER DISEASE
Introduction. The Alzheimer disease (AD) is the socially important neurodegenerative disease. The promising way of the early lifetime diagnosis of the AD is the investigation of the expression of signal molecules by cells in a cerebrospinal fluid, blood lympho…