Table of contents
ОБЗОРЫ
NEUROPEPTIDES AS REGULATORS OF THE INTERACTION BETWEEN CELLULAR OSCILLATORS OF RHYTHMS
Peptidergic structures of the hypothalamus arrange a basis of its unique ability to regulate the organism's functions in time, adjusting metabolism, energy exchange and motor activity as sources of its own energy- to the dynamics of energy intake from external…
INHERITED CARDIOMYOPATHIES: MODERN METHODS OF GENETIC TESTING
Cardiomyopathies are diseases that affect the heart muscle. They are characterized by myocardial dysfunction in the absence or low severity of common cardiovascular diseases, such as coronary atherosclerosis, hypertension, valvular heart diseases. Cardiomyopat…
THE IMPORTANCE OF MORPHOLOGICAL MARKERS IN DIFFERENTIAL DIAGNOSTICS OF SPLEEN INFLAMMATORY MYOFIBROBLASTIC PSEUDOTUMOUR
Introduction. Inflammatory myofibroblastic neoplasm (IMN) of the spleen is extremely rare. It is often benign lesion, represented mainly by fusiform myofibroblasts and inflammatory cells (plasma, lymphocytes and eosinophilic granulocytes). Clinically, the sple…
PD-1 PATH: BIOLOGICAL SIGNIFICANCE, CLINICAL APPLICATION, AND EXISTING PROBLEMS
The review is devoted to the studies of immune check-point (programmed death) molecules – PD-1 receptor and its ligands PD-L1 and PD-L2, which play an important role in the regulation of immune response. Special attention is paid to soluble (s) forms of PD-1 a…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
REPROGRAMMING OF THE GENOME IN ADAPTIVE RESPONSES OF THE CELL
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
ICAM-1, IL-6, TROPONIN-1 IN THE BUCCAL EPITHELIUM AS PREDICTORS OF THE ATHEROSCLEROSIS DEVELOPMENT IN PERSONS OF DIFFERENT AGES
The task of molecular vital diagnosis is to search for peripheral tissues for the verification of biomarkers with the aim of optimization of diagnosis and evaluation of the effectiveness of treatment of socially significant diseases including cardiovascular pa…
COMPLEX F8 GENE REARRANGEMENTS
Introduction. Hemophilia A is a frequent X-linked recessive disorder associated with the absence or functional defect of blood clotting factor VIII. Вoth point mutations and large structural rearrangements – deletions, duplications, and inversions were describ…
ANTIBODIES TO DESAMINATED GLYADIN PEPTIDES, TISSUE TRANSGLUTAMINASE AND ENDOMYSIUM IN HLA-DQ 2/8 GENOTYPE CARRIERS
Introduction. The laboratory diagnosis of celiac disease is based on the detection of antibodies against deamidated gliadin peptides (anti-DGP), autoantibodies to tissue transglutaminase (anti-tTG) and endomysium (AEA), as well as genotyping of HLA-DQ2/8 loci.…
THE STUDY OF THE ACUTE TOXICITY OF NEW RADIOPHARMACEUTICALS 99mTc-1-thio-D-glucose IN THE EXPERIMENT
The aim of the study. To investigate the overall acute toxicity of a new radiopharmaceutical in laboratory animals under the selected experimental conditions. Materials and methods. The study was performed on 80 white outbred rats (weight of males 220–260 g, t…
THE LEVEL OF EXPRESSION OF PROGESTERONE, ESTRADIOL AND VITAMIN D RECEPTORS IN MONONUCLEAR CELLS OF THE PERIPHERAL BLOOD OF PATIENTS WITH SURGICAL MENOPAUSE
Introduction. Patients with surgical menopause are at risk for an osteopenic syndrome. For adequate medical correction of osteoporosis, it is necessary to clarify the mechanisms of the pathogenesis of this condition. It is known that osteoclasts, the activatio…