Table of contents
ОБЗОРЫ
DENDRITIC CELLS IN THERAPY OF BREAST ADENOCARCINOMA
Dendritic cells (DC), as professional antigen-presenting cells with functional plasticity, are widely studied in preclinical and clinical research of vaccines against various types of malignant tumors. Some of the studies DС have proved their efficiency. Howev…
COMPARATIVE ANALYSIS OF METHODS OF MITOCHONDRIAL REPLACEMENT THERAPY
Mitochondrial diseases are a group of inherited diseases characterized by the presence of defects in the mitochondrial mechanism of the patient. The distinguishing feature of such diseases is in transferring it via the maternal line to all the offspring. Vario…
OMICS TECHNOLOGY: THE ROLE AND SIGNIFICANCE FOR PERSONALIZED MEDICINE
Personalized medicine implements new methods of molecular diagnostic for increasing the efficacy of the treatment of patients and the verification of the liability to diseases. Thus the search, development and applying modern methods and technologies of biomed…
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
BRAIN METABOLITES ANALYSIS IN PATIENTS WITH TYPE 2 DIABETES AND COGNITIVE IMPAIREMENT
Introduction. Type 2 diabetes mellitus (DM) is a metabolic disease characterized by prolonged hyperglycemia, which can cause various complications. Some studies have reported on the relationship between changes in cerebral metabolism and glucose levels. The ai…
SKELETON FORMATION AND POLYMORPHISM OF ANDROGEN RECEPTOR GENE IN TRANSSEXUAL INDIVIDUALS
Introduction. The androgen receptor (AR) gene MIGHR is known to be associated with transsexualism. Bone tissue is one of the target organs for androgens. Trochanteric index (TI) (ratio of height to the leg length) may indicate the organism androgenization leve…
THE ROLE AND INTERACTION OF POLYMORPHIC VARIANTS OF NON-ALLELIC GENES KCNJ11, ADIPOQ, ITLN1, LEP, TCF7L2, PPARG IN THE INCREASE IN THE RISK OF DIABETES TYPE 2 IN KYRGYZ REPUBLIC
Aim. To study the intergenic interaction and estimate the contribution of polymorphic loci p.K23E (rs5219, KCNJ11), g.15661G>T (rs1501299, ADIPOQ), p.V109D (rs2274907, ITLN1), g.2453G>A (rs7799039, LEP), g.53341C>T (rs7903146, TCF7L2), and p.P12A (rs1801282, P…
POLYMORPHISM AND SYNERGISM OF THE HEMOSTASIS SYSTEM GENES IN PATHOGENESIS OF INFECTIVE ENDOCARDITIS
Introduction. The genetically determined tendency of patients to thrombosis may be one of the etiopathophysiological factors of the infective endocarditis (IE). Aim. А search for variants of genes and their combinations in the hemostatic system, the carriage o…
GIANT CELL TUMOR OF THE SACRUM: RADIOLOGICAL AND MORPHOLOGICAL CHARACTERISTICS
Introduction. Giant cell tumors (GCT) of bones are benign tumors with the potential for the aggressive course and ability to metastasize. GCT accounts for approximately 5% of all primary bone tumors. Materials and methods. The clinical case of the patient L., …
DBH GENE POLYMORPHISM IN PSORIASIS PATIENTS
Introduction. Psoriasis is a chronic inflammatory autoimmune disease with complex etiology including inheritable factors as well. Some scientists suggest psoriasis to be a systemic disease affecting not only skin. Thus, on the edge of dermatology and psychiatr…