Table of contents
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
DEVELOPMENT OF A PERSONALIZED APPROACH FOR DETERMINING PATHOLOGICAL AREAS IN THE ORAL MUCOSA BASED ON THE DETERMINATION OF THE GINGIVA PERMEABILITY TO METHYLENE BLUE
Introduction. Timely diagnosis and a personalized approach to the treatment of diseases is accepted to be one of the most important modern tasks in medicine and in particular, dentistry. The use of pharmaceuticals for the diagnosis and treatment of various dis…
SINGLE-PHOTON EMISSION COMPUTERIZED TOMOGRAPHY WITH 99mTc-DARPin9_29 IN DIAGNOSTICS OF BREAST CANCER WITH Her2/neu OVEREXPRESSION: FIRST CLINICAL EXPЕRIENCE
Introduction. In recent years, alternative framework proteins are used for the targeted radionuclide imaging. Molecules of DARPin (Design Ankyrin Repeat Protein) are one of the representatives of scaffolds. Despite the continued increase in the number of molec…
DNA Methylation Analysis of Lesional and Non-lesional Skin in Adult Patients with Atopic Dermatitis
Introduction. Atopic dermatitis is a chronic inflammatory disease caused by a complex interaction of genetic, immune, and environmental factors. Recently, the study of epigenetic changes has brought new insights into the etiology of atopic dermatitis. Aim of t…
FEATURES OF METABOLIC ATYPISM DURING THE DEVELOPMENT OF ONCOLOGICAL PATHOLOGY OF THE UROGENITAL SYSTEM
Introduction. Urological and genital malignant neoplasms in men are an urgent problem. Every year, about 403.3 thousand newly diagnosed cases of kidney cancer and 34.5 thousand of penile cancer are registered in the world. With metabolic atypism, a change in a…
MECHANO-MODIFIED FORM OF OROTIC ACID IN THE CORRECTION OF HEPATOPATHY CAUSED BY HYPERHOMOCYSTEINEMIA
Introduction. The therapeutic effect of orotic acid (OA) is limited by the low absorption of the drug from the gАСТrointestinal tract, which can be overcome when the drug is processed by mechanical activation. The aim of the study is a comparative experimental…
ОБЗОРЫ
NMDA RECEPTORS, ANTI-NMDA RECEPTOR ANTIBODIES AND THEIR ROLE IN PSYCHIATRIC AND NEUROINFLAMMATORY DISORDERS
Little is known about the etiology of neuropsychiatric disorders. Glutamate-mediated excitotoxicity is one of the main pathological mechanisms occurring in various types of acute and chronic diseases of the central nervous system. Glutamate is the major excita…
MICROBIOTA AND MELATONIN IN THE SYSTEM “MOTHER–PLACENTA–FETUS”
The review presents literature data that reveal the mechanism of mutual influence of microbiota and melatonin in the unified system «mother–placenta–fetus». There is shown the variety of functions performed by the microbiota, provided by the presence of commun…
MOLECULAR AND GENETIC MARKERS OF SARKOPENIA
Sarcopenia is a progressive and generalized pathology of skeletal muscles of multi-factor nature. The present review focuses on the analysis of molecular genetic markers that may contribute both to sarcopenia risk formation and the variability of diagnosticall…