INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF CHRONIC HEART FAILURE

The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of CHF.
Material and methods. A analysis of the main foreign and domestic sources on PubMed, MedLine, eLIBRARY databases over the last
20 years has been carried out.
Results. In the course of the analysis of published works, the key links in the pathogenesis of CHF (imbalance of neurohumoral systems,
inflammatory theory, metabolic disorders) and changes arising from disturbance of intestinal microbiota composition were compared. The
results of studies where microbiota correction by prescribing antibiotics, probiotics and prebiotics resulted in positive effects on the course and
prognosis in CHF are presented.
Conclusion: Commonality in CHF pathogenesis (imbalance of neurohumoral systems, inflammatory theory and metabolic disorders)
and changes in microbiota disturbances (including those mediated by microbial metabolites and inflammatory cytokines), the positive effects
of pro- and prebiotics both on the microbial composition of the intestine and on course and prognosis in CHF, allow the consideration of
microbiome as a marker and a possible target in CHF therapy. All of the above necessitates for further research in this area.
Key words: intestinal microbiota, chronic heart failure, probiotics, cytokines

M.V. Fadeeva, M.R. Skhirtladze, O.Yu. Zolnikova, V.T. Ivashkin
Sechenov First Moscow State University (Sechenov University), Pogodinskaya str., 1, bld. 1., Moscow, Russian Federation, 119435