Table of contents
ОБЗОРЫ
SARS-CоV-2 INFECTION AS A RISK FACTOR FOR THE DEVELOPMENT OF AUTOIMMUNE PATHOLOGY
Relevance: The review is devoted to the analyses of literature data on disorders of the immune system in COVID-19. Since some of the clinical symptoms of COVID-19 are consistent with those of autoimmune diseases, one of the fundamental questions about COVID-19…
CELL TECHNOLOGIES FOR ENDOMETRIOSIS PATHOGENESIS STUDY
Introduction. Endometriosis is a chronic inflammatory estrogen-dependent disease characterized by the presence of endometrial tissue outside the uterine cavity. The pathogenesis of endometriosis is not fully determined. The relevance of its study is due to the…
FIBROBLAST GROWTH FACTORS AND THEIR EFFECT ON COGNITIVE FUNCTIONS AND THE COURSE OF CENTRAL NERVOUS SYSTEM DEGENERATIVE DISEASES
Aim of investigation. The study of characteristics of fibroblast growth factors (FGFs), as a man factor FGFd, including 22 structurally connected polypeptides, is necessary for the neuroprotection by the CNS degenerative pathology is presented playing a great …
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
THE ROLE OF MARKERS OF INTERCELLULAR INTERACTION IN THE DEVELOPMENT OF ATOPIC DERMATITIS
Introduction. Violation of the skin barrier can be considered as an initial stage in the development of atopic dermatitis, leading to further skin inflammation [2]. Transmembrane proteins such as claudin-1, claudin-7, occludin and E-cadherin are known to be th…
EFFECTIVENESS OF α1А-ADRENORECEPTOR ANTAGONIST IN THE PASSAGE OF MIDDLE STONES FROM THE URETER: THE ROLE OF RECEPTORS COUPLED WITH G-PROTEIN
The study aims to analyze the dependence of an α1А-adrenoreceptor antagonist effectiveness on G-protein-coupled receptors (GPCRs) intracellular signaling in the passage of medium-sized calculi from the ureter. Material and methods. The study was prospective an…
ASSOCIATION OF POLYMORPHIC VARIANTS OF NON-ALLELIC GENES ADIPOQ, MTHFR, PON1, KCNJ11, TCF7L2, ITLN1 AND PPARG WITH CLINICAL AND LABORATORY PARAMETERS AMONG OBESE PATIENTS FROM KYRGYZ REPUBLIC
Introduction. In Kyrgyzstan about 60% of the adult population suffers from lipid metabolism disorders of varying degrees. Early identification of persons at increased risk of developing obesity is of great importance, which can be achieved through the study of…
INFLUENCE OF GABA DERIVATIVES ON THE DNA DAMAGE OF PLACENTA AND FETUSES’S BRAIN AT EXPERIMENTAL PREECLAMPSIA
Gestosis is a complication of the normal course of the gestational process that occurs during pregnancy, childbirth and in the first days of the postpartum period, characterized by a deep disorder of the functions of vital organs and systems. Preeclampsia (PE)…
ANTIGENOTOXIC ACTIVITY OF THE COMBINATION «ASPARTAME + BETAINE» AND METFORMIN IN MICE WITH EXPERIMENTAL STREPTOZOTOCIN DIABETES
Introduction. An increase in DNA damage (genotoxicity) is characteristic of patients with diabetes mellitus. The main complications in diabetes are accompanied and/or initiated by DNA damage. Hence, the necessity to search for and study compounds with antigeno…