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Molecular Medicine
Found: 202
Introduction. Cerebrovascular diseases are a heterogeneous group of conditions shaped by the interaction of polygenic susceptibility, rare monogenic variants, vascular remodeling, neuroinflammation, dysregulated hemostasis, and epigenetic reprogramming. Recent…
Introduction. Single-stranded yeast RNA–ascorbic acid complexes are of interest as a class of natural immunomodulatory systems combining activation of innate immune pattern-recognition receptors with redox-modulating and epigenetic effects of vitamin C. Russia…
Introduction. An aortic aneurysm is defined as an irreversible progressive enlargement of the aorta with an increasing risk of rupture, often fatal. It is known that the imbalance of inhibitors and activators of cell matrix proteolysis and the death of smooth …
Introduction. This review is devoted to the problem of the pathogenesis of pain syndrome in multiple myeloma (MM). The severity of pain often correlates poorly with the plasma cell burden but is highly dependent on tumor aggressiveness determined by primary ge…
coronary artery disease, epithelial-mesenchymal transition, cadherins, connexins, transforming growth factor-β, pannexins
Introduction. Primary open-angle glaucoma is considered a multifactorial disease, in the pathogenesis of which low-grade inflammation, cytokine imbalance, extracellular matrix remodeling, and neuroinflammation play a significant role. In comorbid patients with…
Introduction. Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder, the primary pathological feature of which is the death of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of aggregated α-synuclein. Th…
Tick bite is traditionally viewed in clinical practice primarily as an event associated with the risk of pathogen transmission. Although this interpretation is epidemiologically justified, it does not capture the molecular layer that develops within the first …
Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…
This review systematizes current data on branched-chain aminotransferases (BCATs). Their molecular structure, classification as fold type IV pyridoxal phosphate (PLP)-dependent enzymes, and catalytic features are discussed in detail. The differences between th…
The study is devoted to the identification of changes in the proteomic profile of senescent mesenchymal stromal cells of adipose tissue, which determine the modulation of the macrophage phenotype and are involved in the pathogenetic cascade of the formation of…
Introduction. The incidence of eosinophilic esophagitis is 5.31 cases per 100,000 person-years. It is a multifactorial disease with a clear genetic predisposition, specifically involving the expression of the thymic stromal lymphopoietin and IL-33 genes. Eosin…
Objective. To investigate the role of toxic metabolites of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) in autism spectrum disorders (ASD) pathogenesis and their relationship with intestinal dysbiosis. Material and methods. The study included…
Introduction. Breast cancer (BC) is a heterogeneous disease that represents a major global health problem. It is the most frequently diagnosed cancer in the world, with the incidence of breast cancer increasing year by year in most countries. The existence of …
Metabolic syndrome (MS) is a cluster of conditions including abdominal obesity, hypertension, dyslipidemia, and hyperglycemia that are very common in developed countries. The prevalence of MS increases annually. In recent years, a significant increase in the p…
Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…
The pathogenetic process of sarcopenic obesity (SO) development is multifactorial, the key of them is considered – non-specific systemic inflammation. Objective. to assess the influence of the intensity of the course of chronic inflammation in patients with ty…
Introduction. Innate immunity represents the first line of defense against pathogens, based on recognition of conserved molecular patterns (PAMPs) through specialized pattern recognition receptors (PRRs). RNA-containing viral patterns are of particular importa…
Currently, there is no existing data on the role of asprosin and meteorin-like protein (Metrnl) in the pathogenesis of obesity in children. Purpose of the study. To assess the relationship between the levels of adipomio-cins asprosin and Metrnl with body compo…
Introduction. A physical injury triggers a cascade of pathological processes, including the activation of the immune system and the development of local inflammation. Hereditary predisposition, pronounced structural changes, biomechanical disorders, and comorb…