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Molecular Medicine
Found: 222
Introduction. In spite of active research, no highly specific and sensitive marker of skin melanoma has been found so far. The aim of the study. Studying the level of stem cell factor (SCF), neuron-specific enolase (NSE), sCD44std, and heat shock proteins Hsp2…
Introduction. Interactions of exposed on the tumor cell surface or circulating in the bloodstream molecules MICA with activating receptor NKG2D play an important role in the regulation of antitumor immune response. Accumulation of soluble MICA compromises NKG2…
IL15 proves to be a cytokine that important for innate as well as for adaptive immunity. It is one of the key factors of cell-mediated antiviral response. In this review we touch upon its primary, secondary and tertiary structure and functions, characteristics…
Implantation is the key process for becoming pregnant. Failure of implantation in IVF cycles is one of the main problems of modern reproductology. Search for biomarkers and the determination of the best time and maximal endometrial receptivity for the implemen…
Pathophysiology as a science and curriculum discipline stands in front of the biggest challenge in its history. It extended farbeyond the limits of its historical name and embedded aspects of Pathochemistry, Immunopathology, Pathobiophysics and Pathoinformatic…
«Nothing in biomedicine makes sense except in the light of evolution». From this point of view, genetics of predispositions hasto answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neut…
Genomic and molecular genetic studies of autism can identify new biological markers to determine the etiology and the molecular and cellular mechanisms of the pathogenesis of this disease. In addition to the fundamental importance of this research the laborato…
Introduction.Uveal melanoma (UM) is one of the most frequent intraocular tumors. Mutations in new oncogenes GNAQ and GNA11 are found in more than 50% of UM. GNAQ gene and its homologue GNA11 are coding the alpha subunit of heterotrimeric G-protein with GTPase …
Genetically determined diversity in the activity of enzymes regulating the biotransformation of drugs and xenobiotics - cytochrome P450 (CYP) is one of the main causes of interindividual differences in the response of pharmacotherapy. The objective of this rev…
We have studied BDNF gene Val66Met polymorphism in patients with a high risk of mortality due to stroke or severe head injury. Genotype ValVal rate was higher than that of in the control group in the total sample of subjects (75,5% and 63,6%; χ2=4,63; df=1; p=…
Formation of an effective strategy for managing patients after implantation of an artificial heart valve (АНV), in order to prevent thrombotic complications is an important problem in cardiology. The use of indirect anticoagulants, including warfarin reduces t…
Morphometric studies of the median transverse sections of rat hearts, performed on 28th day after coronary artery ligation, showed that as a result of myocardial infarction the pronounced postinfarction remodelling of the left ventricle of the heart was observ…
Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and predicti…
Abstract: This review summarizes the results of studies devoted to identification the dominant mechanisms of formation and persistence of inflammation in severe asthma. According to the latest research, the most likely causal factors and molecules that underli…
Assessment of the effectiveness of thrombolytic and anticoagulation therapies was performed in 92 patients with pulmonary tromboembolism (PTE), aged from 22 to 88 years (average age is 59,3±13,9 years). In accordance with the diagnostics algorithm of PTE, acce…
aryngeal and laryngopharyngeal cancer response to neoadjuvant chemotherapy as well as to investigate the feasibility of 199Tl-chloride for visualization of primary and recurrent laryngeal tumors. Materials and Methods: The study included 60 patients with stage…
An approach to the development of methodology for health risk assessment (HRA) for the effects of new environmental factors: nanoparticles and nanobiomaterials (NP/NBM) – products of modern nano-, nanobiotechnology has been proposed. The experience from develo…
There is a growing body of evidence confirming the validity of the concept of cancer stem cells (CSCs). It is becoming increasingly obvious that CSCs, possessing higher tumorigenicity, metastasis-initiating activity and chemoresistance, are a source of tumor g…
Introduction. Currently, scientists are paying increasing attention to the genetic condition of various pathologies. According to recent studies, cytokines play an essential role in the immune response in various pathological processes. The detection of geneti…
Introduction. To this date the search for new substances with antitumor activity is an urgent task of pharmacology and medicine. Carrageenans are sulfated galactans of red algae, they are promising substances for the basis of future drugs, as well as for the c…