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Molecular Medicine
Found: 239
Introduction. Galectin-1 binds to cell surface glycoprotein and participates in cooperation of immune cells. It is supposed that the CD4+- lymphocytes can be target for immunosuppressive activity of galectin-1. However, there is no sufficient information about…
Introduction. Preeclampsia is one of the most frequent complications of pregnancy. Disease is based on the pathology of the vascular system of a pregnant woman. One of the candidate genes of preeclampsia is a gene encoding a protein receptor type 2A to activin…
Introduction. The prevalence of human cutaneous melanoma (CM) in the world is constantly rising. Diagnostics and treatment of CM at the early stages allows to increase the 5-year patient survival up to 90%. This problem can be solved with personalized therapy …
Introduction. PI3K/Akt signaling pathway is an important intracellular regulatory mechanism controlling cues of growth factors stimuli, apoptosis, proliferation, and cell motility. Deregulation of activity/expression of PI3K/Akt signaling pathway proteins dete…
The aim of our review article was to analyze different biological effects associated with functional allelic variants of certain genes upon the incidence and clinical course of uterine leiomyoma (UL) and some other hyperplastic uterine disorders. Based on a nu…
Lung cancer is one of the most common oncologic diseases in the world and the most frequent cause of the death from malignant neoplasms. Last decade’s studies revealed significant number of molecular events leading to the onset and development of non-small cel…
Introduction. Insulin-like growth factor signaling system plays a major role in the development and progression of various malignant tumors including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and objects o…
Introduction. P16INK4a protein plays one of the key role in processes of cell proliferation, its inactivation is noted in a number of tumors of various localization. Restoration of the p16INK4a function in neoplastic cells may promote braking of division of tu…
Introduction. The COMT gene encodes for a protein involved in deactivation of genotoxic estrogen species, and the protein product encoded by the L (low activity) allele is 3–5-fold less active than its counterpart encoded by the H (high activity) allele. The a…
Introduction. In spite of active research, no highly specific and sensitive marker of skin melanoma has been found so far. The aim of the study. Studying the level of stem cell factor (SCF), neuron-specific enolase (NSE), sCD44std, and heat shock proteins Hsp2…
Introduction. Hypertrophic cardiomyopathy (HCM) is a common genetically heterogeneous disease caused by mutations in genes encoding proteins of the cardiac sarcomere. Mutations in the genes encoding β-myosin heavy chain (MYH7) and myosin binding protein C (MYB…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
Introduction. The paper presents basic information about the modern role of the IMF in various biochemical processes. Emphasis is placed on the role of MMPs in the pathogenesis of periodontitis. These published data suggest ambiguity of scientific views on the…
Introduction. Matrix metalloproteinase (MMP) – a family of extracellular zinc-containing proteases. There are currently 25 known MMP. Increased activity of MMP observed in some physiological processes – during the follicular phase of the menstrual cycle and du…
Introduction.Uveal melanoma (UM) is one of the most frequent intraocular tumors. Mutations in new oncogenes GNAQ and GNA11 are found in more than 50% of UM. GNAQ gene and its homologue GNA11 are coding the alpha subunit of heterotrimeric G-protein with GTPase …
Introduction. Insulin-like growth factors (IGFs) signaling system plays a key role in development and progression of various malignant tumors, and its components may be considered as prospective diagnostic and prognostic markers and potential objects of target…
The content of VEGF and some components of plasminogen activation system (uPA, PAI-1 and tPA) was determined by enzyme immunoassay methods in the tumors from 121 endometrial cancer patients and in 18 samples of endometrial hyperplasia. Concentrations of uPA an…
The prognosis of one of the most commonly occurring malignancies worldwide – colorectal cancer (CRC) – depends on the development of disease recurrence and distant metastases, most frequently detected in the liver. The aim of our research was to study the asso…
The enhancement of ligand properties of protein molecules treated by toxic reagents has been revealed in model experiments in vitro on ordered protein films. In patients with endogenous intoxication caused by metabolic disorders there were also detected protei…
Salinomycin is referred to the group of the polyether antibiotics with ionophore activity. Currently salinomycin is considered as a potential anticancer drug. The aim of this work was to investigate the cytotoxic activity of salinomycin against MDR1+ (Mel-8) a…