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Molecular Medicine
Found: 230
Introduction. The prevalence of human cutaneous melanoma (CM) in the world is constantly rising. Diagnostics and treatment of CM at the early stages allows to increase the 5-year patient survival up to 90%. This problem can be solved with personalized therapy …
Introduction. Pancreatic ductal adenocarcinoma (PDAC) is notable for its high aggressiveness and low efficiency of diagnostic and treatment approaches. Nuclear receptor HNF4α is one of the possible regulators of the development and differentiation of pancreati…
Introduction. Thymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis and is the main intracellular target of 5-FU. We investigated the clinical and prognostic importance of TYMS gene 5' (TSR2/TSR3 and G>C) and 3' (del 6) untranslated region polym…
Introduction. Progress in the treatment of cancer and bone tumors including, is associated with a significant breakthrough in molecular biology, immunology, understanding the causes of the emergence of the tumor cell, patterns of the development and course of …
Addictive substances, medication, and environmental substances can permanently disrupt fetal brain development, which might ultimately lead to learning difficulties as well as to many types of behavioral disorders in later life. Congenital defects of this kind…
Introduction. Endocrine factors are considered to be important in the etiology of spontaneous abortion. Aim of the study. Histological and immunohistochemical characterization of the expression of estrogen and progesterone receptors in the gravid endometrium d…
Introduction. In spite of active research, no highly specific and sensitive marker of skin melanoma has been found so far. The aim of the study. Studying the level of stem cell factor (SCF), neuron-specific enolase (NSE), sCD44std, and heat shock proteins Hsp2…
Introduction. The features of pathogenesis of main tumors of the female reproductive system are determined by the impact of estrogen on target tissues. In this connection there appears the need to study the regulation of estrogen and progesterone receptors in …
Introduction. One of the main types of a hormonal therapy in the treatment of the cancer of the prostate gland is the antagonists of the NR3C4 (nuclear receptor subfamily 3, group C, member 4) receptor. It blocks binding of man’s hormones with receptors site, …
Introduction. A novel 3S-paradigm of alternative experimental anti-cancer drug testing procedure was developed in parallel with a modern conception of personalized and predictive medicine to reveal both positive and negative effect in each experiment and topre…
Genomic and molecular genetic studies of autism can identify new biological markers to determine the etiology and the molecular and cellular mechanisms of the pathogenesis of this disease. In addition to the fundamental importance of this research the laborato…
The results of biodistribution of intravenously administrated 188Re-zoledronic acid in rats’ body on the model of bone lesions (callus) are presented. Experiments showed that the complex of 188Re-zoledronic acid has the bone-seeking distribution (up to 31,8% I…
Aim. To study a method of risk assessment neovascular age-related macular degeneration (AMD) with the genetic and clinical risk factors. Methods. The study included 255 patients with neovascular AMD (NVAMD) and 119 subjects in control group. Diagnosis and stag…
A study of the influence of vitamins with antioxidant properties (vitamins A, E, C, coenzyme Q10), drugs, antioxidants (etoksidol, meksidol, cytochrome c), B vitamins (В1, В2, В6), and vitamin-like substances taurine and L-carnitine on the phase I xenobiotic-m…
The influence of the DNA minor groove binding ligands on epigenetic silencing in eukaryotic human cells has been demonstrated for the first time. Using HeLa cell population that harbors silent GFP-reporter gene under control of the CMV promoter we demonstrated…
In the article a review of recent data on the molecular nature of neuroendocrine tumors of the pancreas (pancreatic NETs) is presented. The genetic basis of inherited syndromes associated with the development of pancreatic NETs: multiple endocrine neoplasia ty…
To assess the detection and prognostic significance of donor-specific HLA antibodies serum samples from 66 recipients were examined. Donor-specific antibodies (DSA) have been identified in the sera of 15 patients (22,7%). To assess the effect on DSA during the…
Venous thromboembolism (VTE) is a frequent complication associated with increased mortality in cancer patients. The basic role in pathogenesis of thrombotic complication in cancer patients is played by changes in the hemostatic system caused by the tumor itsel…
The main goal of the project was to study the heightened tolerance of the resistant breast cancer cells to hypoxia. Two in vitro cultured breast cancer cell lines, the estrogen-dependent MCF-7 cells and the resistant ER-negative HBL-100 cells were used in the …
Retrospective analysis of data of histological and ultrasound examination of 199 fragments of arterial wall of internal carotid artery obtained during reconstructive operations was conducted. A retrospective analysis of ultrasound data and histological examina…